Matsui K, Toyoshima E, Mano U, Ando K
Yakubutsu Seishin Kodo. 1982 Dec;2(2):77-80.
Rolling mouse Nagoya (RMN), an ataxia mutant mouse, is adequate to checking up the efficacy of drugs on the ataxic movement disorders. The effects of some drugs on the ataxia of RMN were investigated by open field study. The drugs administered to RMN were as follows: TRH, FLA-63, DL-threo-DOPS, phenoxybenzamine and propranolol. Ataxic gait of RMN were remarkably improved by TRH, but remained unchanged by other drugs. The pretreatments with FLA-63, DOPS and phenoxybenzamine were not influenced to the antiataxic effects of TRH, while the pretreatment with propranolol increased the antiataxic effect of TRH in RMN. These results suggest that mechanism of the improvement of ataxic gait by TRH may not be sufficiently explained through only changing norepinephrine metabolism.
滚动小鼠名古屋品系（RMN）是一种共济失调突变小鼠，适用于检测药物对共济失调运动障碍的疗效。通过旷场试验研究了一些药物对RMN共济失调的影响。给予RMN的药物如下：促甲状腺激素释放激素（TRH）、FLA - 63、DL - 苏阿糖型3,4 - 二羟基苯丝氨酸（DL - threo - DOPS）、酚苄明和普萘洛尔。TRH可显著改善RMN的共济失调步态，但其他药物对其步态无影响。FLA - 63、DOPS和酚苄明预处理对TRH的抗共济失调作用无影响，而普萘洛尔预处理可增强TRH对RMN的抗共济失调作用。这些结果表明，TRH改善共济失调步态的机制可能不能仅通过改变去甲肾上腺素代谢来充分解释。
