Biglan A W, Brown D R, Reynolds J D, Milley J R
Ophthalmology. 1984 Dec;91(12):1504-11. doi: 10.1016/s0161-6420(84)34104-5.
The eyes of infants who were premature or had exposure to increased ambient oxygen from 1979 to 1981 were examined. Of 1012 neonates, 19 were found to have acute retrolental fibroplasia (RLF) grade III or worse in at least one eye. Sixteen also had chronic lung disease (CLD), and when compared to 25 control patients who had CLD but not grade III or more RLF, they were found to consistently have lower blood CO2 tensions (PCO2), lower pH values, higher inspired oxygen concentrations (FIO2S) and a higher incidence of seizure disorders (100% vs. 48%). We could not show that an elevated PCO2 increased the risk for developing RLF. Infants with either chronic lung disease or chronic lung disease and seizures had a high risk for developing RLF grade III (39% and 57%, respectively).
对1979年至1981年期间早产或暴露于高环境氧的婴儿的眼睛进行了检查。在1012名新生儿中，发现19名至少一只眼睛患有III级或更严重的急性晶状体后纤维增生症（RLF）。其中16名还患有慢性肺病（CLD），与25名患有CLD但没有III级或更严重RLF的对照患者相比，发现他们的血液二氧化碳分压（PCO2）持续较低、pH值较低、吸入氧浓度（FIO2S）较高且癫痫发作障碍的发生率较高（分别为100%和48%）。我们未能证明PCO2升高会增加发生RLF的风险。患有慢性肺病或慢性肺病合并癫痫的婴儿发生III级RLF的风险较高（分别为39%和57%）。
