Shahinian L, Malachowski N
Arch Ophthalmol. 1978 Jan;96(1):70-4. doi: 10.1001/archopht.1978.03910050034008.
Over an 18-month period, four severe and eight mild cases of retrolental fibroplasia (RLF) were diagnosed. All infants had gestational age less than 34 weeks. While the percentage of infants with RLF increased with decreasing gestational age, the severity of RLF was not related to birth weight or gestational age. These RLF infants were compared with premature infants having normal fundi. The arterial blood gas values in the first week of life were similar for the two groups. However, during the subsequent weeks of oxygen therapy, the infants who developed severe RLF had a significantly greater number of hours of capillary oxygen tension at undesirable levels (Pcap O2 greater than 50 mm Hg) than the mild RLF or control infants. These results suggest that infants may be at greatest risk of severe retinal damage from oxygen relatively late in the course of their oxygen therapy.
在18个月的时间里，共诊断出4例严重和8例轻度晶状体后纤维增生症（RLF）。所有婴儿的胎龄均小于34周。虽然RLF婴儿的比例随着胎龄的降低而增加，但RLF的严重程度与出生体重或胎龄无关。将这些RLF婴儿与眼底正常的早产儿进行比较。两组在出生后第一周的动脉血气值相似。然而，在随后几周的氧疗期间，发生严重RLF的婴儿毛细血管氧张力处于不理想水平（Pcap O2大于50 mmHg）的小时数明显多于轻度RLF婴儿或对照婴儿。这些结果表明，婴儿在氧疗过程相对较晚阶段可能面临因氧气导致严重视网膜损伤的最大风险。
