Santa Cruz A R, Baldi A
Rev Esp Oncol. 1983;30(2):171-8.
It is discussed the rol of lipid intermediates in the biosynthesis of eucaryotic glycoproteins. Microsomal fraction isolated from malignant human breast tumors transferred Man and Glc from GDP-(14 C)-Man and UDP-(14 C)-Glc into lipid linked sugars and glycoproteins. The transference of Dol-PP-oligosaccharide to endogenous acceptor proteins was catalyzed for the same microsomal fraction.
本文讨论了脂质中间体在真核生物糖蛋白生物合成中的作用。从恶性人乳腺肿瘤中分离出的微粒体部分将GDP-(14C)-甘露糖和UDP-(14C)-葡萄糖中的甘露糖和葡萄糖转移到脂质连接糖和糖蛋白中。同一微粒体部分催化了多萜醇焦磷酸寡糖向内源受体蛋白的转移。