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[人类乳腺肿瘤中蛋白质糖基化机制的初始阶段]

[Initial stages in the mechanism of protein glycosylation in human breast neoplasms].

作者信息

Santa Cruz A R, Baldi A

出版信息

Rev Esp Oncol. 1983;30(2):171-8.

PMID:6441202
Abstract

It is discussed the rol of lipid intermediates in the biosynthesis of eucaryotic glycoproteins. Microsomal fraction isolated from malignant human breast tumors transferred Man and Glc from GDP-(14 C)-Man and UDP-(14 C)-Glc into lipid linked sugars and glycoproteins. The transference of Dol-PP-oligosaccharide to endogenous acceptor proteins was catalyzed for the same microsomal fraction.

摘要

本文讨论了脂质中间体在真核生物糖蛋白生物合成中的作用。从恶性人乳腺肿瘤中分离出的微粒体部分将GDP-(14C)-甘露糖和UDP-(14C)-葡萄糖中的甘露糖和葡萄糖转移到脂质连接糖和糖蛋白中。同一微粒体部分催化了多萜醇焦磷酸寡糖向内源受体蛋白的转移。

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1
[Initial stages in the mechanism of protein glycosylation in human breast neoplasms].[人类乳腺肿瘤中蛋白质糖基化机制的初始阶段]
Rev Esp Oncol. 1983;30(2):171-8.
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Mechanism of inhibition of protein glycosylation by the antiviral sugar analogue 2-deoxy-2-fluoro-D-mannose: inhibition of synthesis of man(GlcNAc)2-PP-Dol by the guanosine diphosphate ester.抗病毒糖类似物2-脱氧-2-氟-D-甘露糖抑制蛋白质糖基化的机制:通过鸟苷二磷酸酯抑制甘露糖(N-乙酰葡糖胺)2-焦磷酸-多萜醇的合成。
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Transfer of oligosaccharide from oligosaccharide pyrophosphoryl dolichol to endogenous acceptor proteins in human breast malignant and normal tissues.寡糖从寡糖焦磷酸化多萜醇向人乳腺恶性及正常组织中内源性受体蛋白的转移。
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