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寡糖从寡糖焦磷酸化多萜醇向人乳腺恶性及正常组织中内源性受体蛋白的转移。

Transfer of oligosaccharide from oligosaccharide pyrophosphoryl dolichol to endogenous acceptor proteins in human breast malignant and normal tissues.

作者信息

Santa Cruz A R, Baldi A

出版信息

Experientia. 1985 Jul 15;41(7):928-9. doi: 10.1007/BF01970017.

DOI:10.1007/BF01970017
PMID:4007130
Abstract

We have prepared dolichylpyrophosphoryl-[14C]-oligosaccharide (Dol-PP-oligosaccharide) from calf thyroid. Microsomal fractions from human breast tissues catalyzed the transfer of labeled oligosaccharide to endogenous acceptor proteins. Malignant tumors showed higher activity of the oligosaccharide transferring enzyme than normal tissue. With kojibiose (Kj), an inhibitor of (Glc3)-glucosidase, an increase in the radioactivity associated with glycoprotein was observed.

摘要

我们从小牛甲状腺中制备了焦磷酸多萜醇-[14C]-寡糖（Dol-PP-寡糖）。人乳腺组织的微粒体组分催化标记寡糖向内源性受体蛋白的转移。恶性肿瘤显示出比正常组织更高的寡糖转移酶活性。使用(Glc3)-葡糖苷酶抑制剂 kojibiose（Kj）时，观察到与糖蛋白相关的放射性增加。

相似文献

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Transfer of oligosaccharide from oligosaccharide pyrophosphoryl dolichol to endogenous acceptor proteins in human breast malignant and normal tissues.寡糖从寡糖焦磷酸化多萜醇向人乳腺恶性及正常组织中内源性受体蛋白的转移。
Experientia. 1985 Jul 15;41(7):928-9. doi: 10.1007/BF01970017.
2
[Initial stages in the mechanism of protein glycosylation in human breast neoplasms].[人类乳腺肿瘤中蛋白质糖基化机制的初始阶段]
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Increased transfer of oligosaccharide from oligosaccharide pyrophosphoryl dolichol to protein acceptors upon estrogen-induced chick oviduct differentiation.
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Effect of glucosylation of lipid intermediates on oligosaccharide transfer in solubilized microsomes from Saccharomyces cerevisiae.脂质中间体的糖基化对酿酒酵母溶解微粒体中寡糖转移的影响。
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Catabolic pathway of oligosaccharide-diphospho-dolichol. Study of the fate of the oligosaccharidic moiety in mouse splenocytes.
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引用本文的文献

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本文引用的文献

1
Microsomal glucosidases of rat liver. Partial purification and inhibition by disaccharides.大鼠肝脏微粒体葡萄糖苷酶。部分纯化及二糖对其的抑制作用。
Eur J Biochem. 1980 Dec;113(1):97-103. doi: 10.1111/j.1432-1033.1980.tb06144.x.
2
Subcellular localization of the sedimentable form of mammary tumor glycoprotein to the tumor cell plasmalemma.乳腺肿瘤糖蛋白可沉降形式在肿瘤细胞质膜的亚细胞定位。
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Tumors; a mixed bag of cells.
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Synthesis and processing of asparagine-linked oligosaccharides.天冬酰胺连接寡糖的合成与加工
Annu Rev Biochem. 1981;50:555-83. doi: 10.1146/annurev.bi.50.070181.003011.
5
The biosynthetic pathway of the asparagine-linked oligosaccharides of glycoproteins.糖蛋白中天冬酰胺连接寡糖的生物合成途径。
CRC Crit Rev Biochem. 1982 Apr;12(4):289-326. doi: 10.1080/10409238209104422.
6
Lipid-bound sugars in malignant human breast tumors. Partial characterization of mannosyl and glucosyl transferase activities.恶性人乳腺肿瘤中的脂质结合糖。甘露糖基和葡萄糖基转移酶活性的部分特征
Mol Cell Biochem. 1983;56(1):55-66. doi: 10.1007/BF00228769.
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Formation of lipid-bound oligosaccharides containing mannose. Their role in glycoprotein synthesis.含甘露糖的脂质结合寡糖的形成。它们在糖蛋白合成中的作用。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3390-4. doi: 10.1073/pnas.70.12.3390.
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Lipid-saccharide intermediates in glycoprotein biosynthesis. I. Formation of an oligosaccharide-lipid by thyroid slices and evaluation of its role in protein glycosylation.糖蛋白生物合成中的脂质-糖类中间体。I. 甲状腺切片形成寡糖脂质及其在蛋白质糖基化中作用的评估
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Lipid-bound oligosaccharides in insects.昆虫中的脂结合寡糖
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10
Microsomal glucosidases acting on the saccharide moiety of the glucose-containing dolichyl diphosphate oligosaccharide.
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