de Toranzo E G, Gómez M I, Castro J A
Res Commun Chem Pathol Pharmacol. 1978 Feb;19(2):347-52.
Males from three different strains of mice (GXF; CF1, and Swiss) were compared in their liver response to CCl4 effects. They were capable to intensively activate CCl4 to .CCl3. No CCl4 induced lipid peroxidation was detected in the liver microsomes from any of them. All the strains remakably responded to the CCl4 induced liver damage. Results further strengthen our previous hypothesis that covalent binding of CCl4 reactive metabolites to cellular constituents is more important in relation to liver cell injury than early changes in lipid peroxidation.
对三种不同品系的雄性小鼠（GXF、CF1和瑞士小鼠）的肝脏对四氯化碳作用的反应进行了比较。它们能够将四氯化碳强烈激活为三氯甲烷。在它们任何一种的肝脏微粒体中均未检测到四氯化碳诱导的脂质过氧化。所有品系对四氯化碳诱导的肝损伤均有显著反应。结果进一步强化了我们之前的假设，即四氯化碳反应性代谢产物与细胞成分的共价结合相对于脂质过氧化的早期变化在肝细胞损伤方面更为重要。
