Biesel K W, Ehrinpreis M N, Bhathal P S, Mackay I R, Rose N R
Br J Exp Pathol. 1984 Feb;65(1):125-31.
Mice from many different congenic inbred strains were given an intramuscular injection of carbon tetrachloride (CCl4) in olive oil to determine the genetic influences on induction of, and recovery from, liver damage. Liver and blood samples were taken at days 1, 4 and 7. The degree of necrosis and lymphoid infiltration appeared to be controlled, qualitatively and quantitatively, by both H-2-linked and Ah-linked genes. Strain differences were noted in the patterns of hepatocellular necrosis and the proportions of lymphoid, monocytic and other inflammatory cells which characterized the infiltrating population. Kinetic studies of F1 hybrids from matings between the susceptible BALB/cJ male parent and the resistant SJL/J female parent suggested that two dominant genetic influences play a major role in CCl4-induced liver damage. The gene contributed from the BALB/cJ parent affects the extent of liver necrosis and a second gene from SJL/J augments recovery. These results suggest, therefore, that the CCl4-induced liver damage and subsequent recovery are under multigenic control by H-2, Ah and possibly other genes.
给来自许多不同同源近交系的小鼠肌肉注射溶于橄榄油的四氯化碳（CCl₄），以确定基因对肝损伤的诱导和恢复的影响。在第1、4和7天采集肝脏和血液样本。坏死程度和淋巴细胞浸润在质量和数量上似乎都受H-2连锁基因和Ah连锁基因控制。在肝细胞坏死模式以及构成浸润群体的淋巴细胞、单核细胞和其他炎性细胞比例方面，发现了品系差异。对易感的BALB/cJ雄性亲本与抗性的SJL/J雌性亲本杂交产生的F1杂种进行的动力学研究表明，两种显性基因影响在很大程度上导致了CCl₄诱导的肝损伤。来自BALB/cJ亲本的基因影响肝坏死程度，来自SJL/J的另一个基因促进恢复。因此，这些结果表明，CCl₄诱导的肝损伤及随后的恢复受H-2、Ah以及可能的其他基因的多基因控制。
