Snow G R, Cook M A, Anderson C
Calcif Tissue Int. 1984 Sep;36(5):586-90. doi: 10.1007/BF02405371.
Cortical bone remodeling measurements were carried out on the ribs of 6 spayed and five control Beagle dams which had been subjected to a period of observation equal to more than one sigma of cortical bone remodeling activity. The results of the measurements of static and dynamic parameters indicate that the lack of ovarian hormones does not produce a major alteration in the rates of cortical bone remodeling, but does result in an increase in the number of resorption spaces per mm2 of cortical bone without altering the parameters of bone function. This latter fact supports the hypothesis that decreased levels of circulatory ovarian hormones may influence the duration of the resorption activity as well as possibly uncoupling the resorption/formation (R/F) mechanism of the bone remodeling unit.
对6只已绝育和5只对照比格犬母犬的肋骨进行了皮质骨重塑测量，它们都经历了一段等于皮质骨重塑活动一个标准差以上的观察期。静态和动态参数的测量结果表明，卵巢激素缺乏不会导致皮质骨重塑速率发生重大改变，但会导致每平方毫米皮质骨吸收间隙数量增加，而不会改变骨功能参数。后一事实支持这样的假设，即循环卵巢激素水平降低可能会影响吸收活动的持续时间，并可能使骨重塑单元的吸收/形成（R/F）机制解偶联。
