Kuczyński L, Kuriata M, Ciupka B
Pol J Pharmacol Pharm. 1984 Sep-Oct;36(5):485-91.
Synthesis of 24 new 4 and 5 substituted isothiazole derivatives, containing hydrazine and amino groups at the position 5, and carboxyl, ester, amide, hydrazide, nitrile or ureido group in the position 4 is described. Compounds 4, 6, 8 and 19 show antiinflammatory activity, compound 14 has antiaggregatory properties.
本文描述了24种新的4-和5-取代异噻唑衍生物的合成，这些衍生物在5位含有肼基和氨基，在4位含有羧基、酯基、酰胺基、酰肼基、腈基或脲基。化合物4、6、8和19具有抗炎活性，化合物14具有抗聚集特性。
