Välimäki M J, Härkönen M, Eriksson C J, Ylikahri R H
Alcohol. 1984 Jan-Feb;1(1):89-93. doi: 10.1016/0741-8329(84)90043-0.
The plasma or serum concentrations of testosterone, LH, FSH, PRL, cortisol, 17-hydroxyprogesterone, androstenedione, dehydroepiandrosterone, estrone and estradiol were monitored in 8 healthy male volunteers for a period of 48 hr after administration of one large dose of ethanol (1.75 g/kg BW) within the first 3 hr of the experiment. Each subject served as his own control in an identical experiment without ethanol. Blood alcohol concentration reached a maximum of 1.51 +/- 0.08 g/l (mean +/- SEM) 4 hr after the start of drinking. The maximum decrease in serum testosterone was observed at 12 hr when the serum concentrations of gonadotropins were still unchanged. The decrease in serum testosterone persisted at 24 hr despite increases in the serum levels of LH and FSH. The serum or plasma concentrations of PRL, cortisol, 17-hydroxyprogesterone, androstenedione and dehydroepiandrosterone were clearly increased 4 hr after the start of drinking. The increase in serum cortisol lasted as long as the decrease in serum testosterone. No significant changes were found in plasma concentrations of estrone and estradiol. Our results suggest that in addition to direct testicular effects of alcohol, increased adrenal secretion of cortisol may contribute to the decrease in serum testosterone in men acutely intoxicated with ethanol.
在8名健康男性志愿者身上进行了一项实验，在实验的前3小时内给予一剂大剂量乙醇（1.75克/千克体重），之后48小时监测其血浆或血清中睾酮、促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素（PRL）、皮质醇、17-羟孕酮、雄烯二酮、脱氢表雄酮、雌酮和雌二醇的浓度。在相同的无乙醇实验中，每个受试者作为自身对照。饮酒开始后4小时，血液酒精浓度达到最高值，为1.51±0.08克/升（平均值±标准误）。血清睾酮的最大降幅在12小时观察到，此时促性腺激素的血清浓度仍未改变。尽管LH和FSH的血清水平升高，但血清睾酮在24小时时仍持续下降。饮酒开始后4小时，PRL、皮质醇、17-羟孕酮、雄烯二酮和脱氢表雄酮的血清或血浆浓度明显升高。血清皮质醇的升高与血清睾酮的下降持续时间相同。雌酮和雌二醇的血浆浓度未发现显著变化。我们的结果表明，除了酒精对睾丸的直接作用外，肾上腺皮质醇分泌增加可能导致急性乙醇中毒男性血清睾酮下降。
