Brener Z, Ramirez L E, Krettli A U, Cançado J R
Mem Inst Oswaldo Cruz. 1983 Oct-Dec;78(4):437-42. doi: 10.1590/s0074-02761983000400007.
Antibodies against heart vascular structures and striated muscle cells interstitium (EVI antibodies) persist in Chagas' disease patients who had been cured by specific treatment as demonstrated by negative xenodiagnosis, conventional serology (CS) and complement mediated lysis (CoML). On the other hand, EVI antibodies are either present or absent in treated patients presenting positive CS but negative CoML. Since CoML detects antibodies associated to resistance, EVI antibodies are not likely to participate in the control of T. cruzi infections although they might be induced by cross-reacting antigens of heart cells and the parasite. They are neither necessarily related to antibodies responsible for CS. Absorption with T. cruzi and heart tissue confirms the suggestion that EVI antibodies are induced by a number of antigenic determinants, most from heart structures with a minor participation of T. cruzi antigens.
通过阴性虫媒接种诊断、传统血清学（CS）和补体介导的溶解反应（CoML）证明，在接受过特异性治疗已治愈的恰加斯病患者体内，抗心血管结构和横纹肌细胞间质的抗体（EVI抗体）依然存在。另一方面，在CS呈阳性但CoML呈阴性的接受治疗患者中，EVI抗体要么存在，要么不存在。由于CoML检测与抵抗力相关的抗体，所以EVI抗体虽可能由心肌细胞和寄生虫的交叉反应抗原诱导产生，但不太可能参与对克氏锥虫感染的控制。它们也不一定与引起CS的抗体有关。用克氏锥虫和心脏组织进行吸收试验证实了以下推测：EVI抗体由多种抗原决定簇诱导产生，其中大多数来自心脏结构，克氏锥虫抗原的参与较少。
