Schmuñis G A, Cossio P M, Szarfman A, Coarasa L, Arana R M
J Infect Dis. 1978 Sep;138(3):401-4. doi: 10.1093/infdis/138.3.401.
Antibodies reacting against endothelial cells, vascular structures, and heart and skeletal muscle cells (EVI antibodies) were studied in 10 patients (one to 14 years of age) treated with Nifurtimox. The patients were observed for several months to two years after the onset of symptoms of acute infection with Trypanosoma cruzi. Although these 10 patients were selected because after treatment their sera became negative for antibodies to T. cruzi as detected by the immunofluorescence test, sera from six patients remained positive for EVI antibodies. It is suggested that EVI antibodies may be self-perpetuated in the absence of infection. Further studies are needed to determine the pathogenic significance of EVI antibodies.
在10例接受硝呋莫司治疗的患者（年龄1至14岁）中，研究了针对内皮细胞、血管结构以及心脏和骨骼肌细胞的抗体（EVI抗体）。这些患者在急性克氏锥虫感染症状出现后被观察了数月至两年。尽管这10例患者是因为治疗后其血清通过免疫荧光试验检测对克氏锥虫抗体呈阴性而被挑选出来的，但6例患者的血清EVI抗体仍呈阳性。提示EVI抗体可能在无感染的情况下持续存在。需要进一步研究以确定EVI抗体的致病意义。
