Del Bo A, Sved A F, Reis D J
J Hypertens Suppl. 1984 Dec;2(3):S49-51.
The integrated effects of stimulation of fastigial nucleus (FN) and of concurrent activation of baroreceptors on arterial pressure (AP), heart rate (HR) and vasopressin (VP) release in anaesthetized, paralysed, artificially ventilated rats were investigated. Stimulation of FN blocked the fall in AP and HR elicited by afferent vagal stimulation. It also abolished the atropine-sensitive bradycardia occurring at the peak of the stimulus-elicited pressor elevation in 6-hydroxydopamine treated rats. Sinoaortic denervation plus vagotomy left the cardiovascular responses to FN stimulus unmodified but facilitated FN elicited VP secretion. Vagotomy alone was ineffective. After high spinal cord transection more VP than in the intact condition was secreted after FN stimulation: simultaneous afferent vagal stimulation did not affect the facilitated VP release. Therefore FN stimulation can inhibit the reflex effects on AP and HR from baroreceptors, while the high-(but not the low-) pressure receptors can partly inhibit the VP release elicited by FN stimulation.
研究了刺激小脑顶核（FN）以及同时激活压力感受器对麻醉、麻痹、人工通气大鼠动脉血压（AP）、心率（HR）和血管加压素（VP）释放的综合影响。刺激FN可阻断迷走神经传入刺激引起的AP和HR下降。它还消除了在6-羟基多巴胺处理的大鼠中，刺激引起的血压升高峰值时出现的阿托品敏感型心动过缓。去窦弓神经加迷走神经切断术不改变对FN刺激的心血管反应，但促进了FN引起的VP分泌。单独迷走神经切断术无效。高位脊髓横断后，FN刺激后分泌的VP比完整状态下更多：同时进行迷走神经传入刺激不影响VP释放的促进作用。因此，FN刺激可抑制压力感受器对AP和HR的反射作用，而高（而非低）压力感受器可部分抑制FN刺激引起的VP释放。
