Koivisto V A, Felig P
Ann Intern Med. 1980 Jan;92(1):59-61. doi: 10.7326/0003-4819-92-1-59.
In seven insulin-dependent diabetic subjects the disappearance rate of 125I-labelled short-acting insulin from injection sites in the abdominal wall was 86% greater than from the leg (P less than 0.005) and 30% greater than from the arm (P less than 0.05). Absorption from the arm was 40% greater than from the leg (P less than 0.05). The postprandial rise in plasma glucose concentration varied inversely with the rate of insulin absorption and was 30 to 50 mg/dL less after abdominal than after leg injection; the glycemic response after arm injection was intermediate between that after leg and abdominal injection. These results indicate that changing the insulin injection site from the leg to the abdomen or arm accelerates the absorption of insulin and diminishes the postprandial rise in plasma glucose. Varying insulin injection sites within the same anatomic region rather than between different regions may diminish daily variations in insulin absorption and in metabolic control in insulin-dependent diabetic subjects.
在7名胰岛素依赖型糖尿病患者中，腹壁注射部位125I标记的短效胰岛素消失率比腿部高86%（P<0.005），比手臂高30%（P<0.05）。手臂的吸收比腿部高40%（P<0.05）。餐后血浆葡萄糖浓度的升高与胰岛素吸收速率呈负相关，腹部注射后比腿部注射后低30至50mg/dL；手臂注射后的血糖反应介于腿部和腹部注射之间。这些结果表明，将胰岛素注射部位从腿部改为腹部或手臂可加速胰岛素吸收，并减少餐后血浆葡萄糖的升高。在同一解剖区域内而非不同区域间改变胰岛素注射部位，可能会减少胰岛素依赖型糖尿病患者胰岛素吸收和代谢控制的每日变化。
