A rise in ambient temperature augments insulin absorption in diabetic patients.

The absorption rate of 125I-Actrapid insulin (6 U) from a subcutaneous injection site was examined in six insulin-dependent diabetic patients at ambient temperatures of 20 degrees C and 35 degrees C. During a 4-hr observation period, the insulin disappearance rate at 35 degrees C was 50%-60% greater than at 20 degrees C (p less than 0.01). Despite the small dose of insulin used, plasma glucose levels tended to be 1 to 2 mmole/liter lower at 35 degrees C than at 20 degrees C. These findings indicate that a rise in ambient temperature augments insulin absorption, in insulin-treated diabetic patients.