桑拿浴促使皮下注射部位胰岛素吸收加速。
Sauna-induced acceleration in insulin absorption from subcutaneous injection site.
作者信息
Koivisto V A
出版信息
Br Med J. 1980 Jun 14;280(6229):1411-3. doi: 10.1136/bmj.280.6229.1411.
Abstract
The effect of the Finnish sauna on insulin absorption from a subcutaneous injection site was examined in eight insulin-dependent diabetic patients by measuring externally the disappearance rate of 125I-labelled rapid-acting insulin. The sauna (twice for 25 minutes at 85 degrees C) accelerated insulin absorption by 110% as compared with room temperature (p < 0.01). After the sauna blood glucose concentrations were 3.0-3.3 mmol/1 (54.1-59.5 mg/100 ml) lower than on the control day (p < 0.05). The fall in blood glucose values was proportional to the increased rate of insulin absorption (r = 0.30; p < 0.01). The hypoglycaemic effect of a sauna in insulin-treated diabetics is clearly at least partly due to enhanced insulin absorption from the injection site. Such an effect might be prevented by taking a snack or reducing the insulin dose.
摘要
通过外部测量125I标记的速效胰岛素的消失率，在8名胰岛素依赖型糖尿病患者中研究了芬兰桑拿对皮下注射部位胰岛素吸收的影响。与室温相比，桑拿（85摄氏度下两次，每次25分钟）使胰岛素吸收加速了110%（p < 0.01）。桑拿后血糖浓度比对照日低3.0 - 3.3 mmol/1（54.1 - 59.5 mg/100 ml）（p < 0.05）。血糖值的下降与胰岛素吸收速率的增加成正比（r = 0.30；p < 0.01）。桑拿对接受胰岛素治疗的糖尿病患者的降血糖作用显然至少部分是由于注射部位胰岛素吸收增强。通过吃点零食或减少胰岛素剂量可能会防止这种作用。
相似文献
1
Sauna-induced acceleration in insulin absorption from subcutaneous injection site.桑拿浴促使皮下注射部位胰岛素吸收加速。
Br Med J. 1980 Jun 14;280(6229):1411-3. doi: 10.1136/bmj.280.6229.1411.
2
Influence of heat on insulin absorption: different effects on amorphous and soluble insulins.
Acta Diabetol Lat. 1983 Apr-Jun;20(2):175-8. doi: 10.1007/BF02624918.
3
Effects of leg exercise on insulin absorption in diabetic patients.
N Engl J Med. 1978 Jan 12;298(2):79-83. doi: 10.1056/NEJM197801122980205.
4
Sauna-induced acceleration in insulin absorption.桑拿浴引起的胰岛素吸收加速。
Br Med J. 1980 Jul 26;281(6235):307. doi: 10.1136/bmj.281.6235.307-a.
5
Sauna-induced acceleration in insulin absorption.桑拿浴引起胰岛素吸收加速。
Br Med J. 1980 Aug 30;281(6240):621-2. doi: 10.1136/bmj.281.6240.621-a.
6
Alterations in insulin absorption and in blood glucose control associated with varying insulin injection sites in diabetic patients.糖尿病患者中，胰岛素吸收及血糖控制的改变与胰岛素注射部位的不同有关。
Ann Intern Med. 1980 Jan;92(1):59-61. doi: 10.7326/0003-4819-92-1-59.
7
Recombinant DNA derived monomeric insulin analogue: comparison with soluble human insulin in normal subjects.重组DNA衍生的单体胰岛素类似物：与正常受试者体内可溶性人胰岛素的比较。
BMJ. 1988 Nov 12;297(6658):1236-9. doi: 10.1136/bmj.297.6658.1236.
8
Change in hormones reflecting sympathetic activity in the Finnish sauna.反映芬兰桑拿中交感神经活动的激素变化。
Ann Clin Res. 1976 Aug;8(4):266-71.
9
Absorption and miscibility of regular porcine insulin after subcutaneous injection of insulin-treated diabetic patients.胰岛素治疗的糖尿病患者皮下注射常规猪胰岛素后的吸收与混溶性
Diabetes Care. 1983 Jan-Feb;6(1):6-9. doi: 10.2337/diacare.6.1.6.
10
Management of severely brittle diabetes by continuous subcutaneous and intramuscular insulin infusions: evidence for a defect in subcutaneous insulin absorption.通过持续皮下和肌肉注射胰岛素输注治疗严重脆性糖尿病：皮下胰岛素吸收缺陷的证据
Br Med J (Clin Res Ed). 1981 Jan 31;282(6261):347-50. doi: 10.1136/bmj.282.6261.347.
引用本文的文献
1
The multifaceted benefits of passive heat therapies for extending the healthspan: A comprehensive review with a focus on Finnish sauna.被动热疗法对延长健康寿命的多方面益处：以芬兰桑拿为重点的综合综述
Temperature (Austin). 2024 Feb 25;11(1):27-51. doi: 10.1080/23328940.2023.2300623. eCollection 2024.
2
The artificial pancreas: two alternative approaches to achieve a fully closed-loop system with optimal glucose control.人工胰腺：实现全闭环系统并达到最佳血糖控制的两种替代方法。
J Endocrinol Invest. 2024 Mar;47(3):513-521. doi: 10.1007/s40618-023-02193-2. Epub 2023 Sep 15.
3
Factors Influencing Insulin Absorption Around Exercise in Type 1 Diabetes.影响 1 型糖尿病患者运动时胰岛素吸收的因素。
Front Endocrinol (Lausanne). 2020 Oct 21;11:573275. doi: 10.3389/fendo.2020.573275. eCollection 2020.
4
Wilderness Medical Society Clinical Practice Guidelines for Diabetes Management.荒野医学会糖尿病管理临床实践指南
Wilderness Environ Med. 2019 Dec;30(4S):S121-S140. doi: 10.1016/j.wem.2019.10.003. Epub 2019 Nov 18.
5
[Epidemiology and prevention of heat-related adverse health effects on elderly people].[老年人与热相关不良健康影响的流行病学及预防]
Z Gerontol Geriatr. 2019 Aug;52(5):487-502. doi: 10.1007/s00391-019-01594-4. Epub 2019 Jul 25.
6
Passive heating and glycaemic control in non-diabetic and diabetic individuals: A systematic review and meta-analysis.被动加热与非糖尿病和糖尿病个体的血糖控制：系统评价和荟萃分析。
PLoS One. 2019 Mar 22;14(3):e0214223. doi: 10.1371/journal.pone.0214223. eCollection 2019.
7
Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability.影响皮下注射胰岛素吸收的因素：对变异性的影响。
J Diabetes Res. 2018 Jul 4;2018:1205121. doi: 10.1155/2018/1205121. eCollection 2018.
8
Towards a Physiological Prandial Insulin Profile: Enhancement of Subcutaneously Injected Prandial Insulin Using Local Warming Devices.朝向生理性餐时胰岛素谱：局部温热设备增强皮下注射餐时胰岛素。
Diabetes Ther. 2015 Sep;6(3):257-72. doi: 10.1007/s13300-015-0125-z. Epub 2015 Sep 2.
9
Improved Postprandial Glucose Control Using the InsuPad Device in Insulin-Treated Type 2 Diabetes: Injection Site Warming to Improve Glycemic Control.使用InsuPad装置改善胰岛素治疗的2型糖尿病患者的餐后血糖控制：注射部位加热以改善血糖控制。
J Diabetes Sci Technol. 2015 May;9(3):639-43. doi: 10.1177/1932296815578881. Epub 2015 Apr 16.
10
Improved insulin absorption by means of standardized injection site modulation results in a safer and more efficient prandial insulin treatment. A review of the existing clinical data.通过标准化注射部位调节改善胰岛素吸收可实现更安全、更有效的餐时胰岛素治疗。现有临床数据综述。
J Diabetes Sci Technol. 2015 Jan;9(1):116-22. doi: 10.1177/1932296814555400. Epub 2014 Oct 28.
本文引用的文献
1
Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose.葡萄糖氧化酶、过氧化物酶和邻联茴香胺在血液及尿液葡萄糖测定中的应用
Lancet. 1957 Aug 24;273(6991):368-70. doi: 10.1016/s0140-6736(57)92595-3.
2
Alterations in insulin absorption and in blood glucose control associated with varying insulin injection sites in diabetic patients.糖尿病患者中，胰岛素吸收及血糖控制的改变与胰岛素注射部位的不同有关。
Ann Intern Med. 1980 Jan;92(1):59-61. doi: 10.7326/0003-4819-92-1-59.
3
Absorption of injected insulin. A clinical-pharmacological study.注射胰岛素的吸收。一项临床药理学研究。
Acta Pharmacol Toxicol (Copenh). 1969;27 Suppl 2:1-84. doi: 10.1111/j.1600-0773.1969.tb03069.x.
4
Human cardiovascular adjustments to exercise and thermal stress.人类心血管系统对运动和热应激的适应性调节。
Physiol Rev. 1974 Jan;54(1):75-159. doi: 10.1152/physrev.1974.54.1.75.
5
Glucoregulation during moderate exercise in insulin treated diabetics.
J Clin Endocrinol Metab. 1977 Oct;45(4):641-52. doi: 10.1210/jcem-45-4-641.
6
Mechanism of exercise-induced hypoglycemia in depancreatized dogs maintained on long-acting insulin.长效胰岛素维持下的胰腺切除犬运动诱发低血糖的机制
J Clin Invest. 1977 Feb;59(2):331-7. doi: 10.1172/JCI108645.
7
Effects of leg exercise on insulin absorption in diabetic patients.
N Engl J Med. 1978 Jan 12;298(2):79-83. doi: 10.1056/NEJM197801122980205.
8
Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site.皮下注射胰岛素的吸收动力学。注射部位存在降解的证据。
Diabetologia. 1979 Aug;17(2):97-9. doi: 10.1007/BF01222209.
9
Circulatory regulation during exercise in different ambient temperatures.不同环境温度下运动时的循环调节。
J Appl Physiol Respir Environ Exerc Physiol. 1979 Mar;46(3):430-7. doi: 10.1152/jappl.1979.46.3.430.
10
Adipose tissue blood flow and insulin disappearance from subcutaneous tissue.
Clin Pharmacol Ther. 1979 May;25(5 Pt 1):598-604. doi: 10.1002/cpt1979255part1598.
Zotero 插件