Strauss J S, Stranieri A M, Farrell L N, Downing D T
J Invest Dermatol. 1980 Feb;74(2):66-7. doi: 10.1111/1523-1747.ep12519851.
Sebum production and skin surface lipid composition have been measured during the oral treatment with 13cis-retinoic acid of a group of patients with severe cystic acne. Two hundred and thirty-eight paired samples have been analyzed and compared. A marked, drug-induced decrease in sebum production was accompanied by a decrease in the concentration of wax esters, a slight decrease in the squalene concentration and in increase in the cholesterol concentration in the skin surface lipids. These changes were consonant with changes in the relative contributions of sebum and epidermal lipid to the surface film, except that at very low levels of sebum production there might be preferential preservation of squalene synthesis.
对一组重度囊肿性痤疮患者口服13 -顺式维甲酸治疗期间的皮脂分泌及皮肤表面脂质成分进行了测定。共分析比较了238对样本。药物引起皮脂分泌显著减少，同时皮肤表面脂质中的蜡酯浓度降低，角鲨烯浓度略有下降，胆固醇浓度升高。这些变化与皮脂和表皮脂质对表面膜相对贡献的变化一致，只是在皮脂分泌极低水平时，角鲨烯合成可能会优先保留。
