Fejes M, Pasqualini C D, Braun M
Oncology. 1980;37(2):96-100. doi: 10.1159/000225413.
Murine lymphoid chalones and their in vivo effect was studied. Cytoplasmic extracts were prepared from normal murine spleen lymphocytes. When assayed in vitro, cytoplasmic extracts (CE) were able to inhibit a blastomitogenic phytohemagglutinin (PHA) response of syngeneic and allogeneic normal murine lymphocytes, as well as cell replication of murine lymphoma cells. CE also had an inhibitory effect on human lymphoblastoid cell line division but it had no effect on nonlymphoid cell division. In vivo, CE had an enhancing effect on a murine allogeneic tumor, probably by suppressing the host's immune rejection response.
对小鼠淋巴细胞抑制因子及其体内效应进行了研究。从正常小鼠脾脏淋巴细胞制备细胞质提取物。在体外检测时，细胞质提取物（CE）能够抑制同基因和异基因正常小鼠淋巴细胞的促有丝分裂植物血凝素（PHA）反应，以及小鼠淋巴瘤细胞的细胞复制。CE对人淋巴母细胞系分裂也有抑制作用，但对非淋巴细胞分裂无作用。在体内，CE对小鼠异基因肿瘤有增强作用，可能是通过抑制宿主的免疫排斥反应实现的。
