小鼠骨髓瘤的体外免疫调节。II. 独特型特异性抑制性T细胞对MOPC - 315免疫球蛋白分泌和合成的抑制作用
Immunoregulation of murine myeloma in vitro. II. Suppression of MOPC-315 immunoglobulin secretion and synthesis by idiotype-specific suppressor T cells.
作者信息
Milburn G L, Lynch R G
出版信息
J Exp Med. 1982 Mar 1;155(3):852-62. doi: 10.1084/jem.155.3.852.
Abstract
In previous studies, BALB/c mice immunized with trinitrophenyl-specific IgA protein (M315) produced by MOPC-315 developed idiotype (Id315)-specific T cells that suppressed M315 secretion in vivo. In the present in vitro studies, we show that inhibition of M315 secretion is mediated by a theta,Lyt-1-2+ cell that expresses a surface membrane receptor for Id315. The suppressor signal is a diffusable product that acts directly on M315-secreting myeloma cells. Inhibition of M315 secretion is T cell dose-dependent, Id315-specific, reversible, and occurs without any effect on MOPC-315 growth, viability, or surface membrane expression of M315. Inhibition of M315 secretion results from a selective inhibition of M315 synthesis in the myeloma cell. These studies provide new insight into the mechanisms of direct B cell regulation by idiotype-specific T cells.
摘要
在先前的研究中，用MOPC - 315产生的三硝基苯基特异性IgA蛋白（M315）免疫的BALB/c小鼠产生了独特型（Id315）特异性T细胞，这些T细胞在体内抑制M315的分泌。在目前的体外研究中，我们发现M315分泌的抑制是由表达Id315表面膜受体的θ、Lyt - 1 - 2⁺细胞介导的。抑制信号是一种可扩散的产物，直接作用于分泌M315的骨髓瘤细胞。M315分泌的抑制呈T细胞剂量依赖性、Id315特异性、可逆性，并且对MOPC - 315的生长、活力或M315的表面膜表达没有任何影响。M315分泌的抑制是由于骨髓瘤细胞中M315合成的选择性抑制。这些研究为独特型特异性T细胞直接调节B细胞的机制提供了新的见解。
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