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1
Immunoregulation of murine myeloma in vitro. II. Suppression of MOPC-315 immunoglobulin secretion and synthesis by idiotype-specific suppressor T cells.小鼠骨髓瘤的体外免疫调节。II. 独特型特异性抑制性T细胞对MOPC - 315免疫球蛋白分泌和合成的抑制作用
J Exp Med. 1982 Mar 1;155(3):852-62. doi: 10.1084/jem.155.3.852.
2
Anti-idiotypic regulation of IgA expression in myeloma cells.骨髓瘤细胞中IgA表达的抗独特型调节
Mol Immunol. 1983 Sep;20(9):931-40. doi: 10.1016/0161-5890(83)90035-4.
3
T lymphocyte-mediated suppression of myeloma function in vitro. IV. Generation of effector suppressor cells specific for myeloma idiotypes.T淋巴细胞在体外介导的骨髓瘤功能抑制。IV. 骨髓瘤独特型特异性效应抑制细胞的产生。
J Exp Med. 1982 Apr 1;155(4):1216-21. doi: 10.1084/jem.155.4.1216.
4
Idiotype-specific T cell suppression of light chain mRNA expression in MOPC-315 cells is accompanied by a posttranscriptional inhibition of heavy chain expression.在MOPC - 315细胞中，独特型特异性T细胞对轻链mRNA表达的抑制伴随着重链表达的转录后抑制。
J Mol Cell Immunol. 1984;1(2):115-23.
5
Ligand-induced redistribution and augmentation of surface-bound myeloma protein on MOPC 315 plasmacytoma cells.配体诱导的MOPC 315浆细胞瘤细胞表面结合骨髓瘤蛋白的重新分布和增加。
Scand J Immunol. 1977;6(1-2):59-76. doi: 10.1111/j.1365-3083.1977.tb00322.x.
6
Immunoregulation of murine myeloma: isologous immunization with M315 induces idiotype-specific T cells that suppress IgA secretion by MOPC-315 cells in vivo.小鼠骨髓瘤的免疫调节：用M315进行同源免疫可诱导独特型特异性T细胞，该细胞在体内抑制MOPC - 315细胞分泌IgA。
J Immunol. 1979 May;122(5):2011-9.
7
A small hypervariable segment in the variable domain of an immunoglobulin light chain stimulates formation of anti-idiotypic suppressor T cells.免疫球蛋白轻链可变域中的一个小的高变区刺激抗独特型抑制性T细胞的形成。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5396-400. doi: 10.1073/pnas.79.17.5396.
8
Regulation of myeloma growth in vitro by idiotype-specific T lymphocytes.独特型特异性T淋巴细胞对骨髓瘤体外生长的调节
J Immunol. 1980 Jan;124(1):424-30.
9
Fine specificity analysis of idiotype-specific suppressor factors that block a delayed-type hypersensitivity response to M315: evidence supporting a role for somatic mutations in the variable region of the lambda 2 chain of M315.对阻断针对M315的迟发型超敏反应的独特型特异性抑制因子的精细特异性分析：支持M315的λ2链可变区体细胞突变起作用的证据。
Immunology. 1986 Nov;59(3):365-72.
10
Idiotype-specific T lymphocytes. I. Regulation of antibody production by idiotype-specific H-2-restricted T lymphocytes.独特型特异性T淋巴细胞。I. 独特型特异性H-2限制型T淋巴细胞对抗体产生的调节。
J Immunol. 1983 Mar;130(3):1038-42.

引用本文的文献

1
Suppression of the noninvolved pair of the myeloma isotype correlates with poor survival in newly diagnosed and relapsed/refractory patients with myeloma.骨髓瘤同型中未受累配对的抑制与新诊断及复发/难治性骨髓瘤患者的不良生存相关。
Am J Hematol. 2016 Mar;91(3):295-301. doi: 10.1002/ajh.24268.
2
Differentiation and cancer: the conditional autonomy of phenotype.分化与癌症：表型的条件自主性
Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):647-8. doi: 10.1073/pnas.92.3.647.
3
Consumption of monoclonal anti-idiotypic antibody by neoplastic B lymphocytes: a guide for immunotherapy.肿瘤性B淋巴细胞对单克隆抗独特型抗体的摄取：免疫治疗指南
Br J Cancer. 1984 Sep;50(3):407-13. doi: 10.1038/bjc.1984.190.
4
In vitro synthesis of IgE by human lymphocytes. IV. Suppression of the spontaneous IgE synthesis by IgE-binding factors secreted by tunicamycin-treated RPMI 8866 cells.人淋巴细胞体外合成IgE。IV. 衣霉素处理的RPMI 8866细胞分泌的IgE结合因子对自发IgE合成的抑制作用。
Immunology. 1984 Dec;53(4):783-90.
5
Immune response to myeloma cells and idiotypes.对骨髓瘤细胞和独特型的免疫反应。
Surv Immunol Res. 1983;2(3):315-7. doi: 10.1007/BF02918442.
6
Induction of idiotype-specific suppressor T cells with antigen/antibody complexes.用抗原/抗体复合物诱导独特型特异性抑制性T细胞。
J Exp Med. 1983 Jun 1;157(6):1713-25. doi: 10.1084/jem.157.6.1713.
7
Chemical synthesis of idiotopes. Evidence that antisera to the same JH1 peptide detect multiple binding site-associated idiotopes.独特型表位的化学合成。针对同一JH1肽的抗血清可检测多个与结合位点相关的独特型表位的证据。
J Exp Med. 1984 May 1;159(5):1338-50. doi: 10.1084/jem.159.5.1338.
8
T lymphocyte-mediated suppression of myeloma function in vitro. IV. Generation of effector suppressor cells specific for myeloma idiotypes.T淋巴细胞在体外介导的骨髓瘤功能抑制。IV. 骨髓瘤独特型特异性效应抑制细胞的产生。
J Exp Med. 1982 Apr 1;155(4):1216-21. doi: 10.1084/jem.155.4.1216.
9
Selective elimination of idiotype-binding cells in vivo by a drug-idiotype conjugate demonstrates the functional significance of these cells in immune regulation.药物-独特型缀合物在体内对独特型结合细胞的选择性清除证明了这些细胞在免疫调节中的功能意义。
Proc Natl Acad Sci U S A. 1988 Jun;85(11):3990-4. doi: 10.1073/pnas.85.11.3990.
10
Generation of T cell clones binding F(ab')2 fragments of the idiotypic immunoglobulin in patients with monoclonal gammopathy.单克隆丙种球蛋白病患者中与独特型免疫球蛋白的F(ab')2片段结合的T细胞克隆的产生
Cancer Immunol Immunother. 1991;34(3):157-62. doi: 10.1007/BF01742306.

本文引用的文献

1
A disposable diffusion chamber system used to study immunoregulation by soluble factors.一种用于通过可溶性因子研究免疫调节的一次性扩散室系统。
J Immunol Methods. 1980;39(1-2):147-54. doi: 10.1016/0022-1759(80)90303-8.
2
The regulation of growth and differentiation of a murine B cell lymphoma. I. Lipopolysaccharide-induced differentiation.小鼠B细胞淋巴瘤生长与分化的调控。I. 脂多糖诱导的分化
J Immunol. 1981 Jun;126(6):2461-5.
3
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. IX. Characterization of Idiotype-specific effector-phase suppressor cells on plaque-forming cell responses in vitro.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。IX. 体外针对空斑形成细胞应答的独特型特异性效应期抑制细胞的特性
J Exp Med. 1981 Jun 1;153(6):1445-56. doi: 10.1084/jem.153.6.1445.
4
Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.抗原和受体驱动的调节机制。IV. 携带独特型的I-J+抑制性T细胞因子诱导表达抗独特型受体的二级抑制性T细胞。
J Exp Med. 1980 May 1;151(5):1183-95. doi: 10.1084/jem.151.5.1183.
5
An immunologic network.一个免疫网络。
Contemp Top Immunobiol. 1980;9:205-30. doi: 10.1007/978-1-4615-9131-3_8.
6
Anti-phenyltrimethylamino immunity in mice. II. L-Tyrosine-p-azophenyltrimethylammonium-induced suppressor T cells selectively inhibit the expression of B-cell clones bearing a cross-reactive idiotype.小鼠中的抗苯基三甲基氨基免疫。II. L-酪氨酸对偶氮苯基三甲基铵诱导的抑制性T细胞选择性抑制带有交叉反应性独特型的B细胞克隆的表达。
J Exp Med. 1980 Mar 1;151(3):528-41. doi: 10.1084/jem.151.3.528.
7
T lymphocyte-mediated suppression of myeloma function in vitro. III. Regulation of antibody production in hybrid myeloma cells by T lymphocytes.T淋巴细胞在体外对骨髓瘤功能的介导抑制作用。III. T淋巴细胞对杂交骨髓瘤细胞中抗体产生的调节。
J Exp Med. 1980 Oct 1;152(4):969-78. doi: 10.1084/jem.152.4.969.
8
Idiotype-specific T cell immunity. I. Generation of effector and suppressor T lymphocytes reactive with myeloma idiotypic determinants.独特型特异性T细胞免疫。I. 与骨髓瘤独特型决定簇反应的效应性和抑制性T淋巴细胞的产生。
J Immunol. 1980 Mar;124(3):1160-6.
9
Stability of cytoplasmic ribonucleic acid in a mouse myeloma: estimation of the half-life of the messenger RNA coding for an immunoglobulin light chain.小鼠骨髓瘤中细胞质核糖核酸的稳定性：编码免疫球蛋白轻链的信使核糖核酸半衰期的估计
J Mol Biol. 1974 Feb 5;82(4):469-81. doi: 10.1016/0022-2836(74)90242-3.
10
Cell-bound myeloma proteins on the surface of myeloma cells: potential targets for the immune system.骨髓瘤细胞表面的细胞结合型骨髓瘤蛋白：免疫系统的潜在靶点。
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2295-9. doi: 10.1073/pnas.69.8.2295.

小鼠骨髓瘤的体外免疫调节。II. 独特型特异性抑制性T细胞对MOPC - 315免疫球蛋白分泌和合成的抑制作用

Immunoregulation of murine myeloma in vitro. II. Suppression of MOPC-315 immunoglobulin secretion and synthesis by idiotype-specific suppressor T cells.

作者信息

Milburn G L, Lynch R G

出版信息

J Exp Med. 1982 Mar 1;155(3):852-62. doi: 10.1084/jem.155.3.852.

DOI:10.1084/jem.155.3.852
PMID:6460829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186615/
Abstract

In previous studies, BALB/c mice immunized with trinitrophenyl-specific IgA protein (M315) produced by MOPC-315 developed idiotype (Id315)-specific T cells that suppressed M315 secretion in vivo. In the present in vitro studies, we show that inhibition of M315 secretion is mediated by a theta,Lyt-1-2+ cell that expresses a surface membrane receptor for Id315. The suppressor signal is a diffusable product that acts directly on M315-secreting myeloma cells. Inhibition of M315 secretion is T cell dose-dependent, Id315-specific, reversible, and occurs without any effect on MOPC-315 growth, viability, or surface membrane expression of M315. Inhibition of M315 secretion results from a selective inhibition of M315 synthesis in the myeloma cell. These studies provide new insight into the mechanisms of direct B cell regulation by idiotype-specific T cells.

摘要

在先前的研究中，用MOPC - 315产生的三硝基苯基特异性IgA蛋白（M315）免疫的BALB/c小鼠产生了独特型（Id315）特异性T细胞，这些T细胞在体内抑制M315的分泌。在目前的体外研究中，我们发现M315分泌的抑制是由表达Id315表面膜受体的θ、Lyt - 1 - 2⁺细胞介导的。抑制信号是一种可扩散的产物，直接作用于分泌M315的骨髓瘤细胞。M315分泌的抑制呈T细胞剂量依赖性、Id315特异性、可逆性，并且对MOPC - 315的生长、活力或M315的表面膜表达没有任何影响。M315分泌的抑制是由于骨髓瘤细胞中M315合成的选择性抑制。这些研究为独特型特异性T细胞直接调节B细胞的机制提供了新的见解。