Fraser N B, Main R A, Stewart T W, Thornton E J
Curr Med Res Opin. 1980;6(7):461-5. doi: 10.1185/03007998009109468.
A double-blind, randomized study was carried out in 37 patients with acne vulgaris to compare the efficacy of two similar lotion formulations, one with ('Actinac') and the other without chloramphenicol (4%). Patients used one or other of the two formulations twice daily for the first 4 days and then at night only for the remainder of the 3-month trial period. At the end of the first month's treatment, the group treated with the full formulation showed a statistically significant greater reduction in lesion count score than in the group receiving the formulation without chloramphenicol. Both treatments produced statistically significant reductions in lesion counts at all monthly follow-up visits. After 3-months' treatment, the mean lesion count score was reduced from 28.8 to 9.3 in the full formulation-treated group and from 39.5 to 14.3 in the formulation minus chloramphenicol group, but this difference did not reach statistical significance.
对37例寻常痤疮患者进行了一项双盲随机研究，以比较两种相似洗剂配方的疗效，一种含有（“Actinac”）氯霉素，另一种不含4%的氯霉素。在为期3个月的试验期的前4天，患者每天使用两种配方中的一种两次，然后在接下来的时间里仅在晚上使用。在第一个月治疗结束时，接受完整配方治疗的组在皮损计数评分上的降低比接受不含氯霉素配方治疗的组具有统计学显著差异。在所有月度随访中，两种治疗方法在皮损计数上均产生了统计学显著降低。经过3个月的治疗，完整配方治疗组的平均皮损计数评分从28.8降至9.3，不含氯霉素配方组从39.5降至14.3，但这种差异未达到统计学显著性。
