Guerrier C J, Thornton E J
Curr Med Res Opin. 1980;6(6):377-9. doi: 10.1185/03007998009109454.
A double-blind, randomized trial was carried out in 44 patients with acne vulgaris to assess the effectiveness of two similar topical combination preparations, one containing hydrocortisone acetate ('Actinac') and the other without the steroid, when applied in lotion form. Patients used one or other of the two formulations twice daily for the first 4 days and then at night only for the remainder of the 3-month study period. The results showed that both treatments were effective but the full formulation-treated group showed a better response at the end of the first month's treatment in terms of percentage reduction in lesion count score, although this did not reach statistical significance. After 3 months, the average lesion count scores dropped from 82 to 11 in the full formulation and from 81 to 8 in the formulation minus hydrocortisone group.
对44例寻常痤疮患者进行了一项双盲随机试验，以评估两种相似的外用复方制剂的疗效，一种含有醋酸氢化可的松（“Actinac”），另一种不含类固醇，均制成洗剂形式使用。患者在为期3个月的研究期的前4天每天使用两种制剂中的一种两次，之后仅在夜间使用。结果显示，两种治疗均有效，但在第一个月治疗结束时，完整制剂治疗组在皮损计数评分降低百分比方面显示出更好的反应，尽管未达到统计学显著性。3个月后，完整制剂组的平均皮损计数评分从82降至11，不含氢化可的松制剂组从81降至8。
