Barden H S
Am J Phys Anthropol. 1980 Feb;52(2):169-73. doi: 10.1002/ajpa.1330520203.
Subjects with Down syndrome provide a useful model for investigating the effect of chromosomal aneuploidy on developmental pathways. Studies suggest that a major effect of trisomy is a decrease in developmental stability. The present study examines fluctuating dental asymmetry in Down syndrome. Mesiodistal crown diameters were measured from dental casts of 114 Down syndrome subjects. Correlation coefficients for antimeric permanent teeth served as an index of dental asymmetry. These values were compared with normal values obtained from the literature. Fluctuating dental asymmetry is thought to reflect the relative success of developmental homeostasis in countering developmental disturbances. Down syndrome subjects have significantly increased dental asymmetry. In addition, they show a disproportionate increase in dental asymmetry for those teeth reported to have the least developmental stability. These results support the contention that the chromosomal imbalance in Down syndrome results in amplified developmental instability.
唐氏综合征患者为研究染色体非整倍性对发育途径的影响提供了一个有用的模型。研究表明，三体的一个主要影响是发育稳定性降低。本研究考察了唐氏综合征患者牙齿的波动不对称性。从114名唐氏综合征患者的牙模上测量了近远中牙冠直径。以对应恒牙的相关系数作为牙齿不对称性的指标。将这些值与从文献中获得的正常值进行比较。牙齿的波动不对称性被认为反映了发育稳态在应对发育干扰方面的相对成功程度。唐氏综合征患者的牙齿不对称性显著增加。此外，对于那些据报道发育稳定性最低的牙齿，他们的牙齿不对称性增加得不成比例。这些结果支持了这样的观点，即唐氏综合征中的染色体失衡导致发育不稳定性加剧。
