Cove J H, Cunliffe W J, Holland K T
Br J Dermatol. 1980 Mar;102(3):277-80. doi: 10.1111/j.1365-2133.1980.tb08140.x.
The levels of Propionibacterium acnes (P. acnes) and members of the Micrococcaceae were enumerated in two separate studies. The first investigation on the foreheads of thirty-five mild and thirty-five moderate acne patients showed no significant difference in the bacterial populations of the two groups. The second investigation of twelve patients on 250 mg tetracycline twice daily for 3 months showed no significant difference compared to pre-treatment data in the bacterial population during the successful treatment period. The data indicate that greater numbers of bacteria are not associated with increasing severity of acne and that the effectivenss of oral tetracycline in treating the disease can not be explained by a reduction in the number of viable bacteria.
在两项独立研究中对痤疮丙酸杆菌（P. acnes）和微球菌科成员的水平进行了计数。第一项针对35名轻度痤疮患者和35名中度痤疮患者前额的调查显示，两组的细菌种群没有显著差异。第二项针对12名患者、每天两次服用250毫克四环素、持续3个月的调查显示，在成功治疗期间，细菌种群与治疗前数据相比没有显著差异。数据表明，细菌数量增加与痤疮严重程度增加无关，口服四环素治疗该疾病的有效性无法通过活菌数量的减少来解释。
