Lynch H T, Fusaro R M, Pester J A, Lynch J F
J Med Genet. 1982 Jun;19(3):218-21. doi: 10.1136/jmg.19.3.218.
The Leser-Trelat sign is the sudden appearance and rapid increase in size and number of seborrhoeic keratoses in association with cancer. Twenty cases of this unusual phenomenon have so far been reported in the world literature. More than half involve adenocarcinomas and none was shown to be familial. We report a unique example of a 41-year-old black female and her 74-year-old black mother, both of whom have demonstrated classical clinical-pathological evidence of the Leser-Trelat sign and adenocarcinoma of the breast. The remainder of the family history was negative for cutaneous lesions and cancer. The aetiological and pathogenetic significance of the Leser-Trelat sign in association with carcinoma of the breast in this mother and daughter remains obscure.
Leser-Trelat征是指脂溢性角化病在癌症患者中突然出现且大小和数量迅速增加的现象。世界文献中迄今已报道了20例这种不寻常的现象。其中一半以上涉及腺癌，且均未显示为家族性。我们报告了一个独特的案例，一名41岁的黑人女性及其74岁的黑人母亲，两人均表现出Leser-Trelat征和乳腺癌的典型临床病理证据。家族史的其余部分在皮肤病变和癌症方面为阴性。Leser-Trelat征与这对母女乳腺癌相关的病因学和发病机制意义仍不清楚。
