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头孢哌酮治疗下呼吸道感染

Cefoperazone in lower respiratory tract infections.

作者信息

Woods C J, Ellis-Pegler R B

出版信息

Drugs. 1981;22 Suppl 1:96-9. doi: 10.2165/00003495-198100221-00020.

DOI:10.2165/00003495-198100221-00020
PMID:6456897
Abstract

17 hospitalised patients with a wide variety of common lower respiratory tract infections received at least 6 days of intravenous bolus cefoperazone 1.0g 12-hourly. Disease was caused by Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus, and mixed anaerobes in 1 patient. All isolates were sensitive to cefoperazone. 11 patients were cured, 4 improved, and 2 failed (1 of whom had an anaerobic empyema). Toxicity and side effects were infrequent. In general cefoperazone was effective therapy for these infections.

摘要

17名患有各种常见下呼吸道感染的住院患者接受了至少6天的静脉推注头孢哌酮治疗,剂量为1.0g,每12小时一次。疾病由流感嗜血杆菌、肺炎链球菌、金黄色葡萄球菌引起,1名患者为混合厌氧菌感染。所有分离株对头孢哌酮敏感。11名患者治愈,4名患者病情改善,2名患者治疗失败(其中1名患有厌氧性脓胸)。毒性和副作用不常见。总体而言,头孢哌酮对这些感染是有效的治疗方法。

相似文献

1
Cefoperazone in lower respiratory tract infections.头孢哌酮治疗下呼吸道感染
Drugs. 1981;22 Suppl 1:96-9. doi: 10.2165/00003495-198100221-00020.
2
Cefoperazone versus cefamandole in the treatment of acute bacterial lower respiratory tract infections.头孢哌酮与头孢孟多治疗急性细菌性下呼吸道感染的比较
J Antimicrob Chemother. 1983 Jan;11(1):75-82. doi: 10.1093/jac/11.1.75.
3
Multicentered clinical evaluation of cefoperazone for the treatment of lower respiratory tract infections.头孢哌酮治疗下呼吸道感染的多中心临床评价
Rev Infect Dis. 1983 Mar-Apr;5 Suppl 1:S137-44. doi: 10.1093/clinids/5.supplement_1.s137.
4
Treatment of lower respiratory tract infections with cefoperazone.
Clin Ther. 1983;5(3):243-50.
5
Clinical trials with cefoperazone in the field of internal medicine in Japan.头孢哌酮在日本内科领域的临床试验。
Clin Ther. 1980;3(Spec Issue):159-72.
6
A comparison of cefotaxime and cefoperazone in respiratory tract infections.头孢噻肟与头孢哌酮治疗呼吸道感染的比较。
J Antimicrob Chemother. 1984 Sep;14 Suppl B:301-6. doi: 10.1093/jac/14.suppl_b.301.
7
[Cefoperazone--a new cephalosporin antibiotic with broader spectrum of activity].
Med Klin. 1981 Feb 13;76(4):102-6, 70.
8
[Clinical evaluation of sulbactam/cefoperazone for lower respiratory tract infections. Correlation between the efficacy of sulbactam/cefoperazone and beta-lactamase].
Jpn J Antibiot. 1996 Aug;49(8):800-7.
9
Asian multicenter trial of cefoperazone in respiratory tract infection.头孢哌酮治疗呼吸道感染的亚洲多中心试验。
Clin Ther. 1984;6(6):824-38.
10
The efficacy of cefditoren pivoxil in the treatment of lower respiratory tract infections, with a focus on the per-pathogen bacteriologic response in infections caused by Streptococcus pneumoniae and Haemophilus influenzae: a pooled analysis of seven clinical trials.头孢托仑匹酯治疗下呼吸道感染的疗效,重点关注肺炎链球菌和流感嗜血杆菌所致感染中按病原体的细菌学反应:七项临床试验的汇总分析
Clin Ther. 2006 Dec;28(12):2061-9. doi: 10.1016/j.clinthera.2006.12.010.

引用本文的文献

1
Cefoperazone: A review of its in vitro antimicrobial activity, pharmacological properties and therapeutic efficacy.头孢哌酮:对其体外抗菌活性、药理特性及治疗效果的综述。
Drugs. 1981 Dec;22(6):423-60. doi: 10.2165/00003495-198122060-00002.

本文引用的文献

1
Single-dose pharmacokinetics of cefoperazone following intravenous administration.
Clin Ther. 1980;3(Spec Issue):46-9.
2
Susceptibility of anaerobic bacteria to cefoperazone and other beta-lactam antibiotics.
Clin Ther. 1980;3(Spec Issue):34-8.
3
Microbiological studies on cefoperazone.头孢哌酮的微生物学研究。
Clin Ther. 1980;3(Spec Issue):24-33.
4
Clinical trials with cefoperazone in the field of internal medicine in Japan.
头孢哌酮在日本内科领域的临床试验。
Clin Ther. 1980;3(Spec Issue):159-72.
5
Comparative activity and beta-lactamase stability of cefoperazone, a piperazine cephalosporin.哌嗪头孢菌素头孢哌酮的比较活性及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1979 Aug;16(2):150-7. doi: 10.1128/AAC.16.2.150.