人体皮肤对合成组胺类似物和组胺的感觉反应。
Sensory responses of human skin to synthetic histamine analogues and histamine.
作者信息
Davies M G, Greaves M W
出版信息
Br J Clin Pharmacol. 1980 May;9(5):461-5.
The potential for itch production in human skin of the synthetic analogues of histamine, 2-methyl histamine (an H1-receptor agonist) and 4-methyl histamine and dimaprit (H2-receptor agonists) has been studied in vivo and compared with histamine. Itch thresholds for 2-methyl histamine were consistently much higher than for histamine (P < 0.001). The H1-receptor antagonist chlorpheniramine raised the itch thresholds to 2-methyl histamine and histamine significantly (P < 0.001). Pruritus was not obtained with either 4-methyl histamine or dimaprit. No evidence of synergism between 2-methyl histamine and either 4-methyl histamine or dimaprit was found. The results suggest that histamine-induced pruritus is mediated in part through the H1-receptor and in part via an additional (but probably non-H2) mechanism.
已在体内研究了组胺的合成类似物2-甲基组胺（一种H1受体激动剂）、4-甲基组胺和二甲双胍（H2受体激动剂）在人体皮肤中产生瘙痒的可能性，并与组胺进行了比较。2-甲基组胺的瘙痒阈值始终远高于组胺（P < 0.001）。H1受体拮抗剂氯苯那敏显著提高了2-甲基组胺和组胺的瘙痒阈值（P < 0.001）。4-甲基组胺或二甲双胍均未引起瘙痒。未发现2-甲基组胺与4-甲基组胺或二甲双胍之间存在协同作用的证据。结果表明，组胺诱导的瘙痒部分通过H1受体介导，部分通过其他（但可能不是H2）机制介导。
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