Greaves M W, McDonald-Gibson W
Br Med J. 1973 Sep 22;3(5881):608-9. doi: 10.1136/bmj.3.5881.608.
Prostaglandin E(1) lowers the threshold of human skin to histamine-evoked itching. Though histamine and other mediators may produce itching by a direct action, itching in inflamed skin can also be explained by a pharmacological synergism in which low concentrations of prostaglandins, which do not themselves cause itching, potentiate itching due to histamine and possibly other agents. Alteration of threshold responses of components of inflammation to other mediators may be an important general role of prostaglandins.
前列腺素E(1)降低人体皮肤对组胺诱发瘙痒的阈值。虽然组胺和其他介质可能通过直接作用产生瘙痒，但炎症皮肤中的瘙痒也可以用一种药理协同作用来解释，即低浓度的前列腺素本身不会引起瘙痒，但会增强组胺及可能其他介质引起的瘙痒。前列腺素可能在炎症成分对其他介质的阈值反应改变方面发挥重要的普遍作用。
