A组链球菌和葡萄球菌致热外毒素对小鼠抑制性T淋巴细胞的激活作用。
Activation of murine T-suppressor lymphocytes by group A streptococcal and staphylococcal pyurogenic exotoxins.
作者信息
Schlievert P M
出版信息
Infect Immun. 1980 Jun;28(3):876-80. doi: 10.1128/iai.28.3.876-880.1980.
Abstract
The effect of group A streptococcal pyrogenic exotoxin (PE) type C and staphylococcal PE on the in vitro antibody response to sheep erythrocytes was studied in cultures of mouse spleen cells. Both exotoxins suppressed the day 4 direct plaque-forming cell response when added to the cultures. The maximum suppression was obtained with 1.0 or 0.1 ng of toxin per culture, and the suppressive effect was reversed by addition of gangliosides to the cultures at the same time as the exotoxins. Preincubation of T lymphocytes for 4 days with either exotoxin resulted in the generation of a suppressor cell population, which produced dose-dependent suppression of the direct plaque-forming cell response when added to fresh sheep eyrthrocyte-activated splenocytes. The suppression obtained was not reversed by gangliosides indicating toxin carry-over was not responsible for the effect. B cells, preincubated with exotoxin, failed to suppress the direct plaque-forming cell response of fresh erythrocyte-activated spleen cells.
摘要
在小鼠脾细胞培养物中研究了A组链球菌C型致热外毒素（PE）和葡萄球菌PE对体外抗绵羊红细胞抗体反应的影响。当将两种外毒素添加到培养物中时，它们均抑制了第4天的直接空斑形成细胞反应。每培养物加入1.0或0.1 ng毒素可获得最大抑制效果，并且在加入外毒素的同时向培养物中添加神经节苷脂可逆转抑制作用。用任一种外毒素将T淋巴细胞预孵育4天会产生抑制细胞群，当将其添加到新鲜的经绵羊红细胞激活的脾细胞中时，会对直接空斑形成细胞反应产生剂量依赖性抑制。所获得的抑制作用不能被神经节苷脂逆转，这表明毒素残留不是造成这种效应的原因。用外毒素预孵育的B细胞未能抑制新鲜红细胞激活的脾细胞的直接空斑形成细胞反应。
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