神经节苷脂和单糖对A组链球菌致热外毒素所致非特异性淋巴细胞有丝分裂原性的抑制作用
Ganglioside and monosaccharide inhibition of nonspecific lymphocyte mitogenicity by group A streptococcal pyrogenic exotoxins.
作者信息
Schlievert P M, Schoettle D J, Watson D W
出版信息
Infect Immun. 1980 Jan;27(1):276-9. doi: 10.1128/iai.27.1.276-279.1980.
Abstract
Group A streptococcal pyrogenic exotoxins (SPE) types A, B, and C are potent nonspecific lymphocyte mitogens. The mitogenicity of these exotoxins was inhibited by gangliosides and sialic acid, whereas concanavalin A was unaffected. The capacity of both concanavalin A and SPE-A to stimulate lymphocytes was suppressed by alpha-methyl-D-mannopyranoside. Galactose reduced the activity of SPE-C. The sugars, glucose, N-acetylglucosamine, alpha-methyl-D-glucopyranoside, and fucose, did not affect SPE mitogenicity.
摘要
A、B和C型A组链球菌致热外毒素（SPE）是强效的非特异性淋巴细胞有丝分裂原。这些外毒素的促有丝分裂活性受到神经节苷脂和唾液酸的抑制，而伴刀豆球蛋白A不受影响。伴刀豆球蛋白A和SPE-A刺激淋巴细胞的能力均受到α-甲基-D-甘露吡喃糖苷的抑制。半乳糖降低了SPE-C的活性。葡萄糖、N-乙酰葡糖胺、α-甲基-D-吡喃葡萄糖苷和岩藻糖等糖类不影响SPE的促有丝分裂活性。
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