Schlievert P M, Schoettle D J, Watson D W
Infect Immun. 1980 Jan;27(1):276-9. doi: 10.1128/iai.27.1.276-279.1980.
Group A streptococcal pyrogenic exotoxins (SPE) types A, B, and C are potent nonspecific lymphocyte mitogens. The mitogenicity of these exotoxins was inhibited by gangliosides and sialic acid, whereas concanavalin A was unaffected. The capacity of both concanavalin A and SPE-A to stimulate lymphocytes was suppressed by alpha-methyl-D-mannopyranoside. Galactose reduced the activity of SPE-C. The sugars, glucose, N-acetylglucosamine, alpha-methyl-D-glucopyranoside, and fucose, did not affect SPE mitogenicity.
A、B和C型A组链球菌致热外毒素（SPE）是强效的非特异性淋巴细胞有丝分裂原。这些外毒素的促有丝分裂活性受到神经节苷脂和唾液酸的抑制，而伴刀豆球蛋白A不受影响。伴刀豆球蛋白A和SPE-A刺激淋巴细胞的能力均受到α-甲基-D-甘露吡喃糖苷的抑制。半乳糖降低了SPE-C的活性。葡萄糖、N-乙酰葡糖胺、α-甲基-D-吡喃葡萄糖苷和岩藻糖等糖类不影响SPE的促有丝分裂活性。
