粗糙脉孢菌中细胞质和线粒体亮氨酰转移核糖核酸合成酶的调控
Regulation of cytoplasmic and mitochondrial leucyl-transfer ribonucleic acid synthetases in Neurospora crassa.
作者信息
Gross S R, Horn E W
出版信息
J Bacteriol. 1980 Oct;144(1):447-50. doi: 10.1128/jb.144.1.447-450.1980.
Abstract
The production of cytoplasmic leucyl-transfer ribonucleic acid synthetase activity was found to be reciprocally proportional to that of the corresponding mitochondrial enzyme during logarithmic growth of strains of Neurospora crassa with normal mitochondria. In the presence of cni-3 mutant mitochondria, production of mitochondrial enzyme activity was greatly increased whereas cytoplasmic enzyme production remained constant. The effect of cni-3 on the yield of the two enzyme activities indicated that the regulatory mechanism involved is a complicated one that cannot be accounted for by the relatively simple transcription competition model proposed previously.
摘要
在具有正常线粒体的粗糙脉孢菌菌株对数生长期间，发现细胞质亮氨酰 - 转移核糖核酸合成酶活性的产生与相应的线粒体酶活性呈反比。在存在cni - 3突变线粒体的情况下，线粒体酶活性的产生大大增加，而细胞质酶的产生保持恒定。cni - 3对两种酶活性产量的影响表明，所涉及的调节机制是复杂的，不能用先前提出的相对简单的转录竞争模型来解释。
相似文献
1
Regulation of cytoplasmic and mitochondrial leucyl-transfer ribonucleic acid synthetases in Neurospora crassa.粗糙脉孢菌中细胞质和线粒体亮氨酰转移核糖核酸合成酶的调控
J Bacteriol. 1980 Oct;144(1):447-50. doi: 10.1128/jb.144.1.447-450.1980.
2
Biochemical comparison of the Neurospora crassa wild type and the temperature-sensitive and leucine-auxotroph mutant leu-5. Purification of the cytoplasmic and mitochondrial leucyl-tRNA synthetases and comparison of the enzymatic activities and the degradation patterns.粗糙脉孢菌野生型与温度敏感型及亮氨酸营养缺陷型突变体leu-5的生化比较。细胞质和线粒体亮氨酰-tRNA合成酶的纯化以及酶活性和降解模式的比较。
Eur J Biochem. 1986 Jul 1;158(1):43-9. doi: 10.1111/j.1432-1033.1986.tb09718.x.
3
Regulation of the nuclear genes encoding the cytoplasmic and mitochondrial leucyl-tRNA synthetases of Neurospora crassa.粗糙脉孢菌胞质和线粒体亮氨酰 - tRNA合成酶核基因的调控。
Mol Cell Biol. 1989 Nov;9(11):4645-52. doi: 10.1128/mcb.9.11.4645-4652.1989.
4
Proposed involvement of an internal promoter in regulation and synthesis of mitochondrial and cytoplasmic leucyl-tRNA synthetases of Neurospora.关于内部启动子参与粗糙脉孢菌线粒体和细胞质亮氨酰 - tRNA合成酶调控与合成的推测。
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1172-6. doi: 10.1073/pnas.74.3.1172.
5
Biochemical comparison of the Neurospora crassa wild-type and the temperature-sensitive leucine-auxotroph mutant leu-5. Detailed kinetic comparison of the leucyl-tRNA synthetases.粗糙脉孢菌野生型与温度敏感型亮氨酸营养缺陷型突变体leu-5的生化比较。亮氨酰-tRNA合成酶的详细动力学比较。
Eur J Biochem. 1986 Jul 1;158(1):51-6. doi: 10.1111/j.1432-1033.1986.tb09719.x.
6
Nuclear gene for mitochondrial leucyl-tRNA synthetase of Neurospora crassa: isolation, sequence, chromosomal mapping, and evidence that the leu-5 locus specifies structural information.粗糙脉孢菌线粒体亮氨酰 - tRNA合成酶的核基因：分离、序列、染色体定位以及亮氨酸-5位点指定结构信息的证据
Mol Cell Biol. 1989 Nov;9(11):4631-44. doi: 10.1128/mcb.9.11.4631-4644.1989.
7
Induction of enzymes of the glycerophosphate pathway in leu-5 mutants of Neurospora crassa.粗糙脉孢菌leu-5突变体中磷酸甘油途径酶的诱导作用。
Biochem Genet. 1976 Dec;14(11-12):1057-63. doi: 10.1007/BF00485136.
8
Increased mitochondrial leucyl- and phenylalanyl-tRNA synthetase activity as a result of inhibition of mitochondrial protein synthesis.线粒体蛋白质合成受抑制导致线粒体亮氨酰 - 苯丙氨酰 - tRNA合成酶活性增加。
Nature. 1976 May 27;261(5558):338-40. doi: 10.1038/261338a0.
9
Cytoplasmic leucyl-tRNA synthetase of Neurospora crassa is not specified by the leu-5 locus.粗糙脉孢菌的细胞质亮氨酰 - tRNA合成酶不是由leu - 5基因座所决定的。
Genetics. 1988 Aug;119(4):805-14. doi: 10.1093/genetics/119.4.805.
10
Arginyl-transfer ribonucleic acid and synthetase of Neurospora crassa.粗糙脉孢菌的精氨酰转移核糖核酸及合成酶
Mycologia. 1972 May-Jun;64(3):499-509.
引用本文的文献
1
Chromosomal loci of Neurospora crassa.粗糙脉孢菌的染色体位点。
Microbiol Rev. 1982 Dec;46(4):426-570. doi: 10.1128/mr.46.4.426-570.1982.
本文引用的文献
1
Mutation and "reversion" at the leu-5 locus of neurospora and its effect on the cytoplasmic and mitochondrial leucyl-tRNA synthetases.粗糙脉孢菌亮氨酸-5位点的突变与“回复突变”及其对细胞质和线粒体亮氨酰-tRNA合成酶的影响。
Biochem Genet. 1971 Dec;5(6):505-16. doi: 10.1007/BF00485668.
2
Induction of mitochondrial RNA polymerase in Neurospora crassa.粗糙脉孢菌中线粒体RNA聚合酶的诱导
Nat New Biol. 1972 Dec 13;240(102):195-7. doi: 10.1038/newbio240195a0.
3
Cooperation of mitochondrial and nuclear genes specifying the mitochondrial genetic apparatus in Neurospora crassa.粗糙脉孢菌中线粒体和细胞核基因在指定线粒体遗传装置方面的协作。
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1371-4. doi: 10.1073/pnas.69.6.1371.
4
Increased mitochondrial leucyl- and phenylalanyl-tRNA synthetase activity as a result of inhibition of mitochondrial protein synthesis.线粒体蛋白质合成受抑制导致线粒体亮氨酰 - 苯丙氨酰 - tRNA合成酶活性增加。
Nature. 1976 May 27;261(5558):338-40. doi: 10.1038/261338a0.
5
The cloning of mouse globin and surrounding gene sequences in bacteriophage lambda.
Cold Spring Harb Symp Quant Biol. 1978;42 Pt 2:915-20. doi: 10.1101/sqb.1978.042.01.093.
6
Proposed involvement of an internal promoter in regulation and synthesis of mitochondrial and cytoplasmic leucyl-tRNA synthetases of Neurospora.关于内部启动子参与粗糙脉孢菌线粒体和细胞质亮氨酰 - tRNA合成酶调控与合成的推测。
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1172-6. doi: 10.1073/pnas.74.3.1172.
7
Selection of extranuclear mutants of Neurospora crassa.粗糙脉孢菌核外突变体的筛选。
Genetics. 1976 May;83(1):11-24. doi: 10.1093/genetics/83.1.11.
8
Regulation of cyanide-insensitive respiration in Neurospora.粗糙脉孢菌中氰化物不敏感呼吸的调控
Eur J Biochem. 1976 Feb 16;62(2):217-21. doi: 10.1111/j.1432-1033.1976.tb10150.x.
Zotero 插件