Liu P, Naughton B A, Kolks G A, Kruger R E, Piliero S J, Gordon A S
J Surg Oncol. 1980;15(2):121-32. doi: 10.1002/jso.2930150204.
Double partial hepatectomy (hepx) evokes an elevation in serum erythropoietin (Ep) levels in anephric hypoxic animals when compared to non-hypoxic or sham hepx controls. But this Ep response is significantly lower than that found in singly hepx, anephric hypoxic rats. Double hepx also induces numerous cytological changes in the liver. Extravascular accumulation of fat, fibrous scarring, localized necroses, and multiple abscesses, as well as decreased vascularity, occur following the second hepx. A humoral factor was detected in the serum of these animals that is capable of inducing hepatic Ep production when injected into normal rats 18 hours before nephrectomy and hypoxia. This factor, termed hepatopoietin (Hp), was previously demonstrated in the venous serum of singly hepx rats. The serum from animals subjected to double partial hepx is not as potent in inducing Ep production as the serum from singly hepx animals. The discrepancies noted between the single and double hepx groups is attributed to the necrotic cytological changes described above.
与非缺氧或假手术肝部分切除术对照组相比，双侧部分肝切除术（hep x）可使无肾缺氧动物的血清促红细胞生成素（Ep）水平升高。但这种Ep反应明显低于单侧hep x无肾缺氧大鼠。双侧hep x还会在肝脏中引发大量细胞学变化。第二次hep x后会出现脂肪的血管外积聚、纤维瘢痕形成、局部坏死和多处脓肿，以及血管减少。在这些动物的血清中检测到一种体液因子，在肾切除和缺氧前18小时注射到正常大鼠体内时，该因子能够诱导肝脏产生Ep。这种因子被称为肝细胞生成素（Hp），先前在单侧hep x大鼠的静脉血清中得到证实。接受双侧部分hep x的动物血清在诱导Ep产生方面不如单侧hep x动物的血清有效。单双侧hep x组之间的差异归因于上述坏死性细胞学变化。
