Naughton B A, Liu P, Kolks G A, Arce J M, Piliero S J, Gordon A S
Am J Physiol. 1980 Mar;238(3):E245-52. doi: 10.1152/ajpendo.1980.238.3.E245.
Erythropoietin (Ep) is a glycoprotein hormone that is responsible for mammalian red blood cell production. Adult rat liver regenerating 48-72 h after hepatectomy (hepx) produces elevated levels of Ep in response to hypoxia when compared to sham-operated, anephric hypoxic controls. A factor, termed hepatopoietin (Hp), found in the serum of hepx rats, is capable of stimulating hepatic Ep production when administered to normal rats 18 h prior to hypoxic exposure. Although the hepatic vein is the most potent source of this factor, Hp can also be demonstrated in the systemic arterial circulation. Bilateral nephrectomy (nephrx) of the donor hepx animal 24 h prior to bleeding abolishes this variation, and highest Ep levels are noted when serum from a hepx and nephrx rat is administered to animals immediatley after nephrx and 18 h before hypoxic exposure. Serum derived from hepx male rats displays a greater ability to evoke hepatic Ep production in normal recipients than serum from similarly treated female rats. Regardless of the sex of the hepx donor, Ep elaboration after hypoxia is highest in male recipients. The results indicate that there is a sexual variation in the production of Hp as well as Ep.
促红细胞生成素（Ep）是一种糖蛋白激素，负责哺乳动物红细胞的生成。与假手术、无肾缺氧对照组相比，肝切除术后48 - 72小时再生的成年大鼠肝脏在缺氧时会产生升高水平的Ep。在肝切除大鼠血清中发现的一种名为肝生成素（Hp）的因子，在缺氧暴露前18小时给予正常大鼠时，能够刺激肝脏Ep的产生。虽然肝静脉是该因子最有效的来源，但在体循环动脉中也能检测到Hp。在放血前24小时对供体肝切除动物进行双侧肾切除可消除这种差异，当将肝切除和肾切除大鼠的血清在肾切除后立即以及缺氧暴露前18小时给予动物时，可观察到最高的Ep水平。与经同样处理的雌性大鼠血清相比，肝切除雄性大鼠的血清在正常受体中引发肝脏Ep产生的能力更强。无论肝切除供体的性别如何，缺氧后Ep的产生在雄性受体中最高。结果表明，Hp以及Ep的产生存在性别差异。
