Naughton B A, Piliero J A, Kruger R E, Birnbach D J, Roy M, Piliero S J, Gordon A S
Am J Anat. 1977 Jul;149(3):431-8. doi: 10.1002/aja.1001490308.
Erythropoietin (Ep) is produced mainly by the liver and spleen during fetal and neonatal periods and by the kidney during adolescent and adult life. The liver is also an important extrarenal producer of Ep in the hypoxic, anephric adult animal. Subtotal hepatectomy results in a substantial elevation in serum Ep levels at 30-72 hours after hepatectomy in rats subsequently nephrectomized and rendered hypoxic. Ep production is related to the mass of regenerating liver with peak Ep production occurring during times of greatest tissue proliferation. Regenerative and erythropoietic responses to hepatectomy decline with advancing age. Rats undergoing repeated hepatectomies do not recover full liver mass but the initial rate of regeneration increases following each successive hepatectomy. Ep levels decline in anephric hypoxic rats undergoing multiple hepatectomies when compared to sham-operated controls.
促红细胞生成素（Ep）在胎儿期和新生儿期主要由肝脏和脾脏产生，在青少年和成年期由肾脏产生。在缺氧的无肾成年动物中，肝脏也是Ep的重要肾外产生部位。大鼠在肾切除并缺氧后，进行次全肝切除，术后30 - 72小时血清Ep水平显著升高。Ep的产生与再生肝脏的质量有关，在组织增殖最旺盛时Ep产生达到峰值。随着年龄增长，肝脏切除后的再生和促红细胞生成反应会下降。经历多次肝切除的大鼠不能恢复到完整的肝脏质量，但每次连续肝切除后初始再生速率会增加。与假手术对照组相比，多次肝切除的无肾缺氧大鼠的Ep水平会下降。
