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[慢性多关节炎的金疗法。过敏和毒性副作用的鉴别]

[Gold therapy in chronic polyarthritis. Differentiation of allergic and toxic side effects].

作者信息

Bene E, Megyeri A, Györi J

出版信息

Z Rheumatol. 1980 Mar-Apr;39(3-4):109-16.

PMID:6448525
Abstract

The data from 310 patients treated with gold were analysed. The occurrence of side effects is lower than the average data in the literature: with "Solganal" 21.5%, with "Tauredon" 21%. The clinical importance of the differentiation of toxic and allergic side effects is pointed out. It seems possible to differentiate between the toxic-allergic and the dosage dependent, actually toxic side effects. In cases of toxicity caused by retarded metabolisation the use of the barbiturate enzyme induction made it possible to continue treatment.

摘要

对310例接受金制剂治疗的患者的数据进行了分析。副作用的发生率低于文献中的平均数据:使用“硫代苹果酸金钠”时为21.5%,使用“硫葡金”时为21%。指出了区分毒性和过敏性副作用的临床重要性。似乎可以区分毒性-过敏性副作用和剂量依赖性的实际毒性副作用。在因代谢迟缓导致毒性的情况下,使用巴比妥类酶诱导剂使得继续治疗成为可能。

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