头孢哌酮对非发酵菌和嗜水气单胞菌的体外活性。
In vitro activity of cefoperazone against nonfermenters and Aeromonas hydrophila.
作者信息
Fass R J
出版信息
Antimicrob Agents Chemother. 1980 Sep;18(3):483-6. doi: 10.1128/AAC.18.3.483.
Abstract
The in vitro activity of cefoperazone against 380 strains (33 species and unnamed groups) of nonferenters and 20 strains of Aeromonas hydrophila was studied by a microdilution method of determining minimal inhibitory concentrations. For comparison, the activities of ampicillin, ticarcillin, and cefamandole were simultaneously studied. Cefoperazone was the most active drug against Pseudomonas sp., Achromobacter xylosoxidans, Flavobacterium meningosepticum. Flavobacterium sp. (group IIb), Group IVc biotype 2, Group Ve, and Aeromonas hydrophila. Against other organisms it was equivalent in activity to or less active than comparative antibiotics. The only organisms which were usually resistant to 128 microgram of cefoperazone per ml were strains of Flavobacterium odoratum and Group IIk biotype 1.
摘要
采用微量稀释法测定最低抑菌浓度，研究了头孢哌酮对380株非发酵菌（33个菌种和未命名菌群）及20株嗜水气单胞菌的体外活性。作为对照，同时研究了氨苄西林、替卡西林和头孢孟多的活性。头孢哌酮对假单胞菌属、木糖氧化无色杆菌、脑膜败血黄杆菌、黄杆菌属（IIb组）、IVc生物型2组、Ve组及嗜水气单胞菌活性最强。对其他菌的活性与对照抗生素相当或更低。通常对每毫升128微克头孢哌酮耐药的唯一菌株是芳香黄杆菌和IIk生物型1组。
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