Appelbaum P C, Tamim J, Stavitz J, Aber R C, Pankuch G A
Eur J Clin Microbiol. 1982 Jun;1(3):159-65. doi: 10.1007/BF02019617.
Susceptibility of 341 isolates of non-fermentative gram-negative bacteria to carbenicillin, piperacillin, cefoperazone, moxalactam, cefotaxime, ceftizoxime, and N-formimidoyl thienamycin was determined by the agar dilution and disc diffusion methods. Piperacillin was the most active agent against Pseudomonas aeruginosa, thienamycin the most active against Pseudomonas fluorescens and Pseudomonas putida, and moxalactam the most active against Pseudomonas maltophilia. Piperacillin and thienamycin were the most active agents against the other Pseudomonas species studied. Thienamycin proved to have excellent activity against Acinetobacter calcoaceticus--90% of strains were inhibited by less than or equal to 1 microgram/ml. The two most active drugs against Alcaligenes species were piperacillin and thienamycin, both of which inhibited 90% of isolates at a concentration of 2 micrograms/ml. All drugs were active against Moraxella species. The broad sensitivity spectrum of piperacillin, thienamycin, and the third-generation cephalosporins against non-fermentative gram-negative bacteria indicates their potential use in infections caused by these organisms.
采用琼脂稀释法和纸片扩散法测定了341株非发酵革兰氏阴性菌对羧苄青霉素、哌拉西林、头孢哌酮、拉氧头孢、头孢噻肟、头孢唑肟和N-甲酰亚胺硫霉素的敏感性。哌拉西林是对铜绿假单胞菌活性最强的药物，硫霉素是对荧光假单胞菌和恶臭假单胞菌活性最强的药物，拉氧头孢是对嗜麦芽窄食单胞菌活性最强的药物。哌拉西林和硫霉素是对所研究的其他假单胞菌属活性最强的药物。硫霉素对乙酸钙不动杆菌具有优异的活性——90%的菌株在小于或等于1微克/毫升的浓度下被抑制。对产碱杆菌属活性最强的两种药物是哌拉西林和硫霉素，二者在2微克/毫升的浓度下均能抑制90%的分离株。所有药物对莫拉菌属均有活性。哌拉西林、硫霉素和第三代头孢菌素对非发酵革兰氏阴性菌的广泛敏感谱表明它们在由这些微生物引起的感染中具有潜在用途。
