Gadsby J E, Heap R B, Burton R D
J Reprod Fertil. 1980 Nov;60(2):409-17. doi: 10.1530/jrf.0.0600409.
Oestrogen synthesis by the early embryo in vitro was studied with tissue from pigs, sheep, cows, roe deer, ferrets, cats, rabbits and a plains viscacha. Definitive evidence for aromatase activity and oestrogen synthesis in preimplantation trophoblast was obtained for the pig with the formation of oestrone, oestradiol-17 beta and oestradiol-17 alpha from 3H-labelled androstenedione and dehydroepiandrosterone. Aromatase activity was appreciably lower in all other species studied, and labelled oestrogens were recovered only from incubations of allantochorionic tissue of roe deer, recovered shortly after implantation, and from pooled samples of early embryonic tissue of cows. High aromatase activity in preimplantation trophoblast of pigs was associated with the maternal recognition of pregnancy and the occurrence of superficial implantation in this species.
利用猪、羊、牛、狍、雪貂、猫、兔和平原毛丝鼠的组织，对早期胚胎在体外的雌激素合成进行了研究。在猪的植入前滋养层中，通过从3H标记的雄烯二酮和脱氢表雄酮生成雌酮、雌二醇-17β和雌二醇-17α，获得了芳香化酶活性和雌激素合成的确切证据。在所有其他研究的物种中，芳香化酶活性明显较低，仅从狍植入后不久的尿囊绒毛膜组织培养物以及牛早期胚胎组织的混合样本中回收了标记的雌激素。猪植入前滋养层中的高芳香化酶活性与该物种的母体妊娠识别和浅表植入的发生有关。
