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[40例银屑病患者的HLA - DRw分型]

[HLA-DRw typing in 40 patients with psoriasis].

作者信息

Raffoux C, Streiff F, Blum F, Weber M, Beurey J

出版信息

C R Seances Soc Biol Fil. 1980;174(1):28-32.

PMID:6449979
Abstract

40 unrelated patients with psoriasis vulgaris were studied for their HLA-A, B and DRw antigens phenotypes. All underwent a skin biopsy to confirm diagnosis. Like most of the authors, we observed an increase in B 13 and B 17 antigens (17,50 % and 25 %) whereas in the healthy populations the percentage was (5 % and 6,02 %) respectively. The strongest increase in DRw7 suggest that the psoriasis vulgaris was associated with DRw7 antigens, with a linkage desequilibrium between the B 13 and DRw7 antigens and between the B 17 and DRw7 antigens.

摘要

对40例寻常型银屑病患者的HLA - A、B和DRw抗原表型进行了研究。所有患者均接受皮肤活检以确诊。和大多数作者一样,我们观察到B13和B17抗原增加(分别为17.50%和25%),而在健康人群中该百分比分别为(5%和6.02%)。DRw7抗原增加最为明显,提示寻常型银屑病与DRw7抗原相关,且B13与DRw7抗原之间以及B17与DRw7抗原之间存在连锁不平衡。

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