Pollack M S, Livingston P O, Fogh J, Carey T E, Oettgen H F, Dupont B
Tissue Antigens. 1980 Mar;15(3):249-56. doi: 10.1111/j.1399-0039.1980.tb00915.x.
Studies of the expression of HLA and DR alloantigens on cultured human melanoma cells in comparison with those expressed on peripheral lymphocytes and B-cells derived from the same patients have shown that the HLA-A,B, and C locus antigens expressed on the cultured tumor cells were consistent with those expected from the typing of peripheral blood lymphocytes. One melanoma cell line failed to express all the HLA antigens expected from donor typing. All five of the lines tested also expressed DR antigens and in three instances these could be demonstrated to have genetically consistent allotypes. However, in preliminary studies stimulation of allogeneic lymphocytes by the DR positive melanoma cells could not be demonstrated.
对培养的人黑色素瘤细胞上 HLA 和 DR 同种异体抗原表达的研究，与来自同一患者的外周淋巴细胞和 B 细胞上表达的抗原进行比较，结果表明，培养的肿瘤细胞上表达的 HLA - A、B 和 C 位点抗原与外周血淋巴细胞分型预期的抗原一致。一个黑色素瘤细胞系未能表达供体分型预期的所有 HLA 抗原。所测试的所有五个细胞系也表达 DR 抗原，在三个实例中，这些抗原被证明具有基因一致的同种异型。然而，在初步研究中，未证实 DR 阳性黑色素瘤细胞能刺激同种异体淋巴细胞。
