Grosshans E, Dungler T, Kien T T, Kremer M
Z Hautkr. 1980 Sep 15;55(18):1211-8.
When the immunological mechanism of the demodectic mange is well-known in dogs, few things are known about the role of Demodex mites in the pathogenesis of rosacea: the purpose of this study is the research of immunological reactions against Demodex antigens in 31 patients (24 papulopustular rosaceas and 7 granulomatous demodectic rosaceas histologically ascertained). Cultures or survival in vitro of human Demodex mites could not be obtained; therefore demodectic cysts of diseased goats (Demodex caprae) were gathered and soluble antigens were extracted by lyophilization. By different immunoserological methods, Demodex specific antibodies could be demonstrated in sera of rosacea (22%), of diseased goats and of rabbits sensitized with small amounts of demodectic antigen. Frequently cross-reactions were observed.
虽然犬蠕形螨病的免疫机制已为人熟知，但关于蠕形螨在酒渣鼻发病机制中的作用却知之甚少：本研究的目的是对31例患者（24例丘疹脓疱型酒渣鼻和7例经组织学确诊的肉芽肿性蠕形螨酒渣鼻）针对蠕形螨抗原的免疫反应进行研究。无法获得人蠕形螨的培养物或体外存活样本；因此，收集了患病山羊（山羊蠕形螨）的蠕形螨囊肿，并通过冻干提取可溶性抗原。通过不同的免疫血清学方法，在酒渣鼻患者（22%）、患病山羊以及用少量蠕形螨抗原致敏的兔子的血清中均可检测到蠕形螨特异性抗体。经常观察到交叉反应。
