前列腺素依赖性调节正常供体以及结核病或麻风病患者外周血淋巴细胞对分枝杆菌抗原的体外增殖反应。
Prostaglandin-dependent regulation of the in vitro proliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal donors and from patients with tuberculosis or leprosy.
作者信息
Bahr G M, Rook G A, Stanford J L
出版信息
Clin Exp Immunol. 1981 Sep;45(3):646-53.
The response to soluble mycobacterial antigens of peripheral blood mononuclear cells, from most normal donors, tuberculosis patients or cases of tuberculoid leprosy (TT/BT) was enhanced by the addition of indomethacin. In contrast, indomethacin caused no enhancement of the response of cells from lepromatous leprosy (BL/LL) cases. Moreover the addition of 10-5 M prostaglandin E2 (PGE2) failed to inhibit the proliferative responses of cells from the BL/LL patients, although it markedly inhibited the responses of peripheral blood mononuclear cells from the other groups. The addition of PGE2 or indomethacin to cells which had been precultured for 48 hr had no significant effect on the proliferative responses of cells from any of the groups of donors. These results suggest that a normal, prostaglandin-dependent, indomethacin-sensitive regulatory mechanism is absent from the peripheral blood mononuclear cells of BL/LL patients.
对于大多数正常供体、肺结核患者或结核样麻风（TT/BT）患者外周血单个核细胞对可溶性分枝杆菌抗原的反应，添加吲哚美辛可增强其反应。相比之下，吲哚美辛对瘤型麻风（BL/LL）患者细胞的反应没有增强作用。此外，添加10⁻⁵ M前列腺素E2（PGE2）未能抑制BL/LL患者细胞的增殖反应，尽管它能显著抑制其他组外周血单个核细胞的反应。向预先培养48小时的细胞中添加PGE2或吲哚美辛，对任何供体组细胞的增殖反应均无显著影响。这些结果表明，BL/LL患者外周血单个核细胞缺乏正常的、依赖前列腺素的、对吲哚美辛敏感的调节机制。
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