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1
Use of gene cloning to determine polarity of an operon: genes carAB of Escherichia coli.利用基因克隆确定操纵子的极性：大肠杆菌的carAB基因
J Bacteriol. 1980 Aug;143(2):921-5. doi: 10.1128/jb.143.2.921-925.1980.
2
Patterns of polarity in the Escherichia coli car AB gene cluster.大肠杆菌car AB基因簇中的极性模式。
J Bacteriol. 1980 Aug;143(2):914-20. doi: 10.1128/jb.143.2.914-920.1980.
3
Multiple regulatory signals in the control region of the Escherichia coli carAB operon.大肠杆菌carAB操纵子调控区域中的多种调控信号。
Proc Natl Acad Sci U S A. 1984 Jul;81(13):4139-43. doi: 10.1073/pnas.81.13.4139.
4
DNA sequence of the carA gene and the control region of carAB: tandem promoters, respectively controlled by arginine and the pyrimidines, regulate the synthesis of carbamoyl-phosphate synthetase in Escherichia coli K-12.carA基因的DNA序列以及carAB的控制区域：串联启动子分别受精氨酸和嘧啶调控，调节大肠杆菌K-12中氨甲酰磷酸合成酶的合成。
Proc Natl Acad Sci U S A. 1984 Jul;81(13):4134-8. doi: 10.1073/pnas.81.13.4134.
5
Nucleotide sequence of the carA gene and regulation of the carAB operon in Salmonella typhimurium.鼠伤寒沙门氏菌中carA基因的核苷酸序列及carAB操纵子的调控
Eur J Biochem. 1988 Sep 15;176(2):421-9. doi: 10.1111/j.1432-1033.1988.tb14299.x.
6
carP, involved in pyrimidine regulation of the Escherichia coli carbamoylphosphate synthetase operon encodes a sequence-specific DNA-binding protein identical to XerB and PepA, also required for resolution of ColEI multimers.参与大肠杆菌氨甲酰磷酸合成酶操纵子嘧啶调节的carP编码一种与XerB和PepA相同的序列特异性DNA结合蛋白，这也是解决ColEI多聚体所必需的。
J Mol Biol. 1995 Jul 21;250(4):392-406. doi: 10.1006/jmbi.1995.0385.
7
Purine and pyrimidine-specific repression of the Escherichia coli carAB operon are functionally and structurally coupled.大肠杆菌carAB操纵子的嘌呤和嘧啶特异性阻遏在功能和结构上是相互关联的。
J Mol Biol. 2004 Feb 6;336(1):25-42. doi: 10.1016/j.jmb.2003.12.024.
8
carP, a novel gene regulating the transcription of the carbamoylphosphate synthetase operon of Escherichia coli.carP，一种调控大肠杆菌氨甲酰磷酸合成酶操纵子转录的新基因。
J Mol Biol. 1988 Dec 20;204(4):857-65. doi: 10.1016/0022-2836(88)90046-0.
9
Genetic and biochemical characterization of the birA gene and its product: evidence for a direct role of biotin holoenzyme synthetase in repression of the biotin operon in Escherichia coli.birA基因及其产物的遗传和生化特性：生物素全酶合成酶在大肠杆菌生物素操纵子阻遏中直接作用的证据。
J Mol Biol. 1981 Mar 15;146(4):469-92. doi: 10.1016/0022-2836(81)90043-7.
10
Cloning of a yeast gene coding for arginine-specific carbamoyl-phosphate synthetase.编码精氨酸特异性氨甲酰磷酸合成酶的酵母基因的克隆。
Proc Natl Acad Sci U S A. 1982 Apr;79(7):2240-4. doi: 10.1073/pnas.79.7.2240.

引用本文的文献

1
Regulation of carbamoylphosphate synthesis in Escherichia coli: an amazing metabolite at the crossroad of arginine and pyrimidine biosynthesis.大肠杆菌中氨甲酰磷酸合成的调控：精氨酸和嘧啶生物合成交汇点处的神奇代谢物。
Amino Acids. 2018 Dec;50(12):1647-1661. doi: 10.1007/s00726-018-2654-z. Epub 2018 Sep 20.
2
Linkage map of Escherichia coli K-12, edition 10: the traditional map.大肠杆菌K-12连锁图谱，第10版：传统图谱。
Microbiol Mol Biol Rev. 1998 Sep;62(3):814-984. doi: 10.1128/MMBR.62.3.814-984.1998.
3
Structure and regulation of the carAB operon in Pseudomonas aeruginosa and Pseudomonas stutzeri: no untranslated region exists.铜绿假单胞菌和施氏假单胞菌中carAB操纵子的结构与调控：不存在非翻译区。
J Bacteriol. 1994 May;176(9):2532-42. doi: 10.1128/jb.176.9.2532-2542.1994.
4
Salmonella typhimurium mutants with altered expression of the pyrA gene due to changes in RNA polymerase.由于RNA聚合酶发生变化而导致pyrA基因表达改变的鼠伤寒沙门氏菌突变体。
EMBO J. 1982;1(9):1141-5. doi: 10.1002/j.1460-2075.1982.tb01309.x.
5
Molecular basis for modulated regulation of gene expression in the arginine regulon of Escherichia coli K-12.大肠杆菌K-12精氨酸调节子中基因表达调控的分子基础。
Nucleic Acids Res. 1983 Aug 11;11(15):5007-19. doi: 10.1093/nar/11.15.5007.
6
Linkage map of Escherichia coli K-12, edition 7.大肠杆菌K-12连锁图谱，第7版。
Microbiol Rev. 1983 Jun;47(2):180-230. doi: 10.1128/mr.47.2.180-230.1983.
7
DNA sequence of the carA gene and the control region of carAB: tandem promoters, respectively controlled by arginine and the pyrimidines, regulate the synthesis of carbamoyl-phosphate synthetase in Escherichia coli K-12.carA基因的DNA序列以及carAB的控制区域：串联启动子分别受精氨酸和嘧啶调控，调节大肠杆菌K-12中氨甲酰磷酸合成酶的合成。
Proc Natl Acad Sci U S A. 1984 Jul;81(13):4134-8. doi: 10.1073/pnas.81.13.4134.
8
The carB gene of Escherichia coli: a duplicated gene coding for the large subunit of carbamoyl-phosphate synthetase.大肠杆菌的carB基因：一个编码氨甲酰磷酸合成酶大亚基的重复基因。
Proc Natl Acad Sci U S A. 1983 Aug;80(15):4629-33. doi: 10.1073/pnas.80.15.4629.
9
Patterns of polarity in the Escherichia coli car AB gene cluster.大肠杆菌car AB基因簇中的极性模式。
J Bacteriol. 1980 Aug;143(2):914-20. doi: 10.1128/jb.143.2.914-920.1980.
10
Biosynthesis and metabolism of arginine in bacteria.细菌中精氨酸的生物合成与代谢
Microbiol Rev. 1986 Sep;50(3):314-52. doi: 10.1128/mr.50.3.314-352.1986.

本文引用的文献

1
In vitro synthesis of Escherichia coli carbamoylphosphate synthase: evidence for participation of the arginine repressor in cumulative repression.大肠杆菌氨甲酰磷酸合成酶的体外合成：精氨酸阻遏物参与累积阻遏的证据。
J Bacteriol. 1980 Jan;141(1):58-66. doi: 10.1128/jb.141.1.58-66.1980.
2
Patterns of polarity in the Escherichia coli car AB gene cluster.大肠杆菌car AB基因簇中的极性模式。
J Bacteriol. 1980 Aug;143(2):914-20. doi: 10.1128/jb.143.2.914-920.1980.
3
Studies of novel transducing variants of lambda: dispensability of genes N and Q.λ新型转导变体的研究：基因N和Q的非必需性
Virology. 1969 Oct;39(2):348-52. doi: 10.1016/0042-6822(69)90060-9.
4
Control of the biosynthesis of carbamoyl phosphate in Escherichia coli.大肠杆菌中氨甲酰磷酸生物合成的调控
J Mol Biol. 1965 Nov;14(1):23-36. doi: 10.1016/s0022-2836(65)80226-1.
5
Regulation and mutation affecting a glutamine dependent formation of carbamyl phosphate in Escherichia coli.影响大肠杆菌中谷氨酰胺依赖性氨甲酰磷酸形成的调控与突变
Biochem Biophys Res Commun. 1964 Feb 18;15(1):76-81. doi: 10.1016/0006-291x(64)90106-8.
6
Physiology and genetics of carbamoylphosphate synthesis in Escherichia coli K12.大肠杆菌K12中氨甲酰磷酸合成的生理学与遗传学
Mol Gen Genet. 1974;133(4):299-316. doi: 10.1007/BF00332706.
7
Reversible dissociation of the monomer of glutamine-dependent carbamyl phosphate synthetase into catalytically active heavy and light subunits.谷氨酰胺依赖性氨甲酰磷酸合成酶单体可逆解离为具有催化活性的重链和轻链亚基。
J Biol Chem. 1974 Jan 25;249(2):492-9.
8
Mutations affecting uridine monophosphate pyrophosphorylase or the argR gene in Escherichia coli. Effects on carbamoyl phosphate and pyrimidine biosynthesis and on uracil uptake.影响大肠杆菌中尿苷单磷酸焦磷酸化酶或argR基因的突变。对氨甲酰磷酸和嘧啶生物合成以及尿嘧啶摄取的影响。
Mol Gen Genet. 1972;118(3):235-45. doi: 10.1007/BF00333460.
9
A simple method for making new transducing lines of coliphage lambda.一种制备新型λ噬菌体转导系的简单方法。
Mol Gen Genet. 1975;137(2):101-7. doi: 10.1007/BF00341676.
10
Studies on the cleavage of bacteriophage lambda DNA with EcoRI Restriction endonuclease.用EcoRI限制性内切酶切割噬菌体λ DNA的研究。
J Mol Biol. 1975 Jan 25;91(3):315-28. doi: 10.1016/0022-2836(75)90383-6.

利用基因克隆确定操纵子的极性：大肠杆菌的carAB基因

Use of gene cloning to determine polarity of an operon: genes carAB of Escherichia coli.

作者信息

Crabeel M, Charlier D, Weyens G, Feller A, Piérard A, Glansdorff N

出版信息

J Bacteriol. 1980 Aug;143(2):921-5. doi: 10.1128/jb.143.2.921-925.1980.

DOI:10.1128/jb.143.2.921-925.1980
PMID:6451616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC294395/
Abstract

A gene-cloning approach was used to determine the transcription polarity of the carbamoylphosphate operon (carAB) of Escherichia coli. In agreement with the accompanying paper (J. Bacteriol. 143:914-920, 1980), our results lead to the conclusion that carA is the proximal gene of the carAB operon.

摘要

采用基因克隆方法来确定大肠杆菌氨甲酰磷酸操纵子（carAB）的转录极性。与同期论文（《细菌学杂志》143:914 - 920, 1980）一致，我们的结果得出结论：carA是carAB操纵子的近端基因。