Spina C A, Smith D, Korn E, Fahey J L, Grossman H J
Am J Dis Child. 1981 Mar;135(3):251-5. doi: 10.1001/archpedi.1981.02130270043015.
Cell-associated immunocompetence was evaluated in 42 patients with Down's syndrome (DS) and compared with that of institutionalized patient control and normal control groups. B lymphocytes, as both percent of total lymphoid cells and absolute number, were markedly reduced in patients with DS. T-lymphocyte proliferative response to phytohemagglutinin mitogen also was significantly decreased. This altered response of the lymphocyte population was evident in both the presence and absence of accessory helper monocytes. Increased Fc receptor (FcR) cell activity, as measured by antibody-dependent cellular cytotoxicity was seen in both the patients with DS and the control patients. This probably resulted from common environmental factors such as exposure to infectious factors such as exposure to infectious agents. No change was found in the WBC counts, percentages of lymphocytes and monocytes, percentages of t cells and FcR cells, or in the natural killer cell activity.
对42例唐氏综合征（DS）患者的细胞相关免疫能力进行了评估，并与收容机构中的患者对照组和正常对照组进行了比较。DS患者的B淋巴细胞，无论是占总淋巴细胞的百分比还是绝对数量，均显著减少。T淋巴细胞对植物血凝素丝裂原的增殖反应也显著降低。无论是否存在辅助性单核细胞，淋巴细胞群体的这种改变的反应都是明显的。通过抗体依赖性细胞毒性测定，DS患者和对照患者的Fc受体（FcR）细胞活性均增加。这可能是由常见的环境因素引起的，如接触感染因子，如接触传染源。白细胞计数、淋巴细胞和单核细胞百分比、T细胞和FcR细胞百分比或自然杀伤细胞活性均未发现变化。
