Hausen B M
Derm Beruf Umwelt. 1981;29(1):18-21.
Allergic Contact Dermatitis due to Feverfew Tanacetum parathenium, Asteraceae. After breeding and selling a new ornamental form of feverfew (Tanacetum parthenium (L.) Schulz-Bip. = Chrysanthemum parthenium (L.) Bernh.), sold the flower markets under the misleading name, "chamomile", a 40 year old female florist developed after a half year handling recurrent dermatitis of the face, neck, hands and forearms. Epicutaneous tests revealed positive reactions to 10 species of the Compositae family, including chrysanthemums, aster Gaillardia. Arnica and truc chamomile. However, the strongests results were seen with petals and leaves of feverfew. Renewed strong reactions to parthenolid, the main sesquiterpene lactonic constitutent of European feverfew demonstrated that this compound was the responsible contact allergen. The sensitizing capacity of parthenolid has been shown in previous investigations in guina pigs. Furthermore, cross-reactionsto parthenolid were frequently observed in chrysanthemum sensitive persons. Mexican samples of feverfew contain the eudesmanolid santamarin and traces of other sesquiterpene lactones, but parthenolid is lacking. Further studies are needed to clarify the sensitizing potency of this related compound.
菊科植物小白菊（Tanacetum parathenium）引起的变应性接触性皮炎。一位40岁的女性花店店主在培育并售卖了一种新的小白菊观赏品种（Tanacetum parthenium (L.) Schulz-Bip. = Chrysanthemum parthenium (L.) Bernh.）后，以误导性的名称“洋甘菊”在花卉市场销售。在处理这种花半年后，她的面部、颈部、手部和前臂出现了复发性皮炎。皮肤试验显示，她对包括菊花、紫菀、天人菊、山金车和真正的洋甘菊在内的10种菊科植物呈阳性反应。然而，对小白菊的花瓣和叶子反应最为强烈。对小白菊内酯（欧洲小白菊的主要倍半萜内酯成分）再次出现强烈反应，表明该化合物是引起接触过敏的过敏原。在之前对豚鼠的研究中已表明小白菊内酯具有致敏能力。此外，对菊花敏感的人经常观察到对小白菊内酯的交叉反应。墨西哥产的小白菊样本含有桉叶烷型倍半萜内酯圣amarin以及其他痕量倍半萜内酯，但不含小白菊内酯。需要进一步研究以阐明这种相关化合物的致敏效力。
