Nishinarita S, Takizawa I, Hirai H, Morita K, Amaki I
J Rheumatol. 1981 Jan-Feb;8(1):19-30.
Peripheral blood lymphocytes or T and B cells from systemic lupus erythematosus (SLE) patients and normal individuals were stimulated with pokeweed mitogen and the intracytoplasmic immunoglobulin positive cells were observed. From the results of coculture of normal and SLE cells, it was postulated that SLE patients had not only a loss of suppressor T cell activity but abnormal B cell function. Further experiments showed that these abnormalities in SLE lymphocytes remained in spite of corticosteroid treatment or inactive disease.
用美洲商陆丝裂原刺激系统性红斑狼疮（SLE）患者和正常个体的外周血淋巴细胞或T细胞和B细胞，并观察胞浆内免疫球蛋白阳性细胞。根据正常细胞与SLE细胞共培养的结果推测，SLE患者不仅抑制性T细胞活性丧失，而且B细胞功能异常。进一步的实验表明，尽管进行了皮质类固醇治疗或疾病处于非活动期，SLE淋巴细胞的这些异常仍然存在。
