Poikonen K, Oka M, Möttönen T, Jokinen I, Arvilommi H
Ann Rheum Dis. 1982 Dec;41(6):607-11. doi: 10.1136/ard.41.6.607.
We studied the production of immunoglobulins by lymphocytes separated from the blood of 15 rheumatoid arthritis (RA) patients, of 12 patients suffering from other connective tissue diseases (CTD), and of 18 healthy controls. The production of IgM, IgG and IgA in pokeweed-mitogen-stimulated cultures was measured by counting the number of plaque-forming cells (PFC) and by determining the concentration of secreted immunoglobulins by means of an enzyme immunoassay. Synthesis of immunoglobulins, particularly IgM and IgG, was lower than in other CTD patients or controls. The IgM response of RA patients was 20% and 29% (PFC and Ig concentrations) that of the controls. The respective figures for IgG were 33% and 53% and for IgA 61% and 72%.
我们研究了从15名类风湿性关节炎（RA）患者、12名患有其他结缔组织疾病（CTD）的患者以及18名健康对照者的血液中分离出的淋巴细胞产生免疫球蛋白的情况。通过计数空斑形成细胞（PFC）的数量以及借助酶免疫测定法测定分泌型免疫球蛋白的浓度，来检测在商陆有丝分裂原刺激培养物中IgM、IgG和IgA的产生情况。免疫球蛋白的合成，尤其是IgM和IgG的合成，低于其他CTD患者或对照者。RA患者的IgM反应（PFC和Ig浓度）分别为对照者的20%和29%。IgG的相应数字分别为33%和53%，IgA的相应数字分别为61%和72%。
