Argyris B F
Transplantation. 1981 May;31(5):334-8. doi: 10.1097/00007890-198105010-00006.
Neonatal mice exhibit high suppressor cell activity that can be measured by the ability of their spleen cells to suppress the in vitro response of adult mouse spleen cells to alloantigens in mixed lymphocyte culture. In this paper we have compared the changes in splenic suppressor cell activity after birth with the changes in immunological maturity, the latter being measured by mixed lymphocyte reactivity of the neonatal spleen cells. The data indicate that there are significant strain differences in the postnatal changes of suppressor cell activity. The results further indicate that four of the five mouse strains tested (C57BL/6, B10.A(5R), B10.A, and DBA/2) demonstrate a good correlation between the decrease in suppressor cell activity and increase in mixed lymphocyte reactivity of mouse spleen cells after birth. In one strain (B10.A(3R)), however, the suppressor cell activity drops to adult levels before full mixed lymphocyte reactivity is achieved. The results suggest that, although suppressor cells may have a role in immunological maturation, other factors may contribute to the development of immunocompetence.
新生小鼠表现出较高的抑制细胞活性，这种活性可以通过其脾细胞在混合淋巴细胞培养中抑制成年小鼠脾细胞对同种异体抗原的体外反应的能力来衡量。在本文中，我们比较了出生后脾抑制细胞活性的变化与免疫成熟度的变化，后者通过新生脾细胞的混合淋巴细胞反应性来衡量。数据表明，抑制细胞活性的产后变化存在显著的品系差异。结果进一步表明，所测试的五个小鼠品系中的四个（C57BL/6、B10.A(5R)、B10.A和DBA/2）在出生后抑制细胞活性的降低与小鼠脾细胞混合淋巴细胞反应性的增加之间表现出良好的相关性。然而，在一个品系（B10.A(3R)）中，在完全达到混合淋巴细胞反应性之前，抑制细胞活性就降至成年水平。结果表明，尽管抑制细胞可能在免疫成熟中起作用，但其他因素可能有助于免疫能力的发展。
