Argyris B F
Transplantation. 1983 Sep;36(3):328-33. doi: 10.1097/00007890-198309000-00019.
Suppressor cell activity is high in the spleen of newborn mice. The injection of adult mouse peritoneal exudate macrophages into newborn mice decreases the neonatal suppressor cell activity. Peritoneal exudate cells from thioglycollate and proteose-peptone pretreated adult mice are effective. Blocking the Fc-receptor on thioglycollate-induced macrophages eliminates their ability to reduce the neonatal suppressor cell activity. Peritoneal exudate cells from Corynebacterium-parvum-pretreated adult mice are not effective. The macrophage cell line, P388, also fails to decrease neonatal suppressor cell activity. A soluble macrophage factor, possibly Interleukin-1, is involved in the interaction between macrophages and suppressor cells. Stimulation of endogenous neonatal macrophage production with thioglycollate does not affect suppressor cell activity. The results are interpreted in the light of the hypothesis that a gradual increase in the number and/or function of macrophages after birth, results in a gradual decrease in suppressor cell activity, allowing for immunocompetence to emerge.
新生小鼠脾脏中的抑制细胞活性较高。将成年小鼠腹腔渗出巨噬细胞注射到新生小鼠体内可降低新生抑制细胞的活性。来自经巯基乙酸盐和蛋白胨预处理的成年小鼠的腹腔渗出细胞是有效的。阻断巯基乙酸盐诱导的巨噬细胞上的Fc受体可消除其降低新生抑制细胞活性的能力。来自经短小棒状杆菌预处理的成年小鼠的腹腔渗出细胞无效。巨噬细胞系P388也无法降低新生抑制细胞的活性。一种可溶性巨噬细胞因子，可能是白细胞介素-1，参与了巨噬细胞与抑制细胞之间的相互作用。用巯基乙酸盐刺激内源性新生巨噬细胞产生并不影响抑制细胞活性。根据出生后巨噬细胞数量和/或功能逐渐增加导致抑制细胞活性逐渐降低从而使免疫能力得以出现这一假设来解释这些结果。
