Rodgers B M, Maher J W, Talbert J L
Ann Surg. 1981 May;193(5):606-11. doi: 10.1097/00000658-198105000-00010.
The surgical management of large body wall defects presents special challenges. The prosthetic materials employed for these defects, although readily available, have the disadvantage of susceptibility to infection. Autologous tissue is frequently not available in sufficient quantity. The long-term functional and histologic results of the use of preserved human dura for closure of abdominal wall and diaphragmatic defects have been evaluated. Dural patches were sutured into abdominal wall and diaphragmatic defects of six dogs, using interrupted sutures of Dexon and Prolene. The animals were killed eight, 16 and 24 weeks after patch placement. The strength of the material was tested with a pneumoperitoneum prior to death and in all animals it appeared firmly incorporated into the host tissue. Histologically there was a mononuclear inflammatory response seen at eight weeks, with resolution by 24 weeks. Ingrowth of surrounding collagen and muscular tissue produced a firm union between the homologous material and the host tissue. The results of this study indicate that preserved human dura is an excellent material for closure of body wall defects. It appears to be well tolerated by host tissue and maintains its strength over prolonged periods of time.
大面积体壁缺损的手术治疗面临特殊挑战。用于这些缺损的人工合成材料虽容易获得，但存在易感染的缺点。自体组织常常数量不足。已对使用保存的人硬脑膜修复腹壁和膈肌缺损的长期功能及组织学结果进行了评估。将硬脑膜补片用Dexon和Prolene间断缝线缝合到6只狗的腹壁和膈肌缺损处。在补片植入后8周、16周和24周处死动物。在处死前用气腹法测试材料的强度，在所有动物中材料似乎都牢固地融入宿主组织。组织学上，8周时可见单核炎性反应，24周时消退。周围胶原和肌肉组织长入在同种材料与宿主组织之间形成牢固连接。本研究结果表明，保存的人硬脑膜是修复体壁缺损的优良材料。它似乎能被宿主组织良好耐受，并在较长时间内保持其强度。
