Van den Eeckhout E, Belpaire F
Acta Psychiatr Belg. 1978 Jan-Feb;78(1):64-8.
The treatment with neuroleptic drugs, such as the butyrophenones, has been based on clinical empiricism, rather than on pharmacokinetic knowledge or on a clear understanding of the mode of action of the drugs. To obtain pharmacokinetic data a specific and sensitive analytical method is necessary. The determination of butyrophenones in a biological medium poses many analytical problems, due to the low dose of these drugs. Very recently Forsman published a pharmacokinetic study of haloperidol in man by electron capture detection. No such study is available for bromperidol. In our paper, we will present comparative data for the quantitative determination of bromperidol by mass fragmentography, gas chromatography with electron capture detection, and radioimmunoassay. Our results show that for the determination of bromperidol in plasma, only radioimmunoassay is sensitive enough to allow the easy determination of the low plasma levels to be expected for bromperidol.
使用抗精神病药物（如丁酰苯类药物）进行治疗一直基于临床经验，而非药代动力学知识或对药物作用方式的清晰理解。为了获得药代动力学数据，需要一种特异且灵敏的分析方法。由于这些药物剂量较低，在生物介质中测定丁酰苯类药物存在许多分析难题。最近，福斯曼通过电子捕获检测发表了一篇关于氟哌啶醇在人体中的药代动力学研究。目前尚无关于溴哌利多的此类研究。在我们的论文中，我们将展示通过质量碎片分析法、带电子捕获检测的气相色谱法和放射免疫分析法对溴哌利多进行定量测定的对比数据。我们的结果表明，对于血浆中溴哌利多的测定，只有放射免疫分析法灵敏度足够高，能够轻松测定出溴哌利多预期的低血浆水平。
